Hoechst Japan Limited

Nippon Electric Co., Ltd.

Kazuyuki Doi

Naotoshi Higashiyama

Masayoshi Koyama

Mikiko Takahashi

Yukio Kato

Michio Kimura

Haiou Pan

Protein having an affinity for a heparin-binding growth factor

Pharmaceutical composition for preventing or treating bone fracture comprising as an active ingredient a platelet factor 4. The present composition can promote differentiation of osteoblasts so that they are effective for prophylaxis and treatment of such diseases requiring bone differentiation and proliferation as bone fracture and the like.

Medicine for preventing and curing bone fracture

The invention is directed to purified and isolated concanavalin A-binding proteins from chondrocytes that are not present in dedifferentiated cells from chondrocytes. The invention is also directed to a purified and isolated chondrocyte membrane protein, (CMP), which is a concanavalin A-binding protein, with a molecular weight of about 76 kD in SDS-PAGE. After treatment with endoglycosidase, CMP has an apparent molecular weight of about 67 kD. The N-terminal amino acid sequence and several internal amino acid sequences are given for CMP. These proteins can be used in assays, methods, or treatments involving differentiation of chondrocytes and the control of cartilaginous osteogenesis.

Concanavalin a binding proteins and a 76kD chondrocyte membrane protein

A protein named PHBP-70 having a wound-healing activity which has a molecular weight of about 60-80 KDa by analysis with SDS-PAGE under reducing conditions and can be obtained from the blood of the fetus and neonates of mammals including human beings. The protein PHBP-70 is a novel protein having a fibroblast proliferating activity and thus it is useful as a wound-healing agent.

Protein PHBP-70

A stereo signal demodulator includes a switching circuit for separating the stereo composite signal into left and right signal components. A composite stereo signal is attenuated in a preset quantity and superimposed upon the left and right signal components after they are separated by the switching circuit. The superimposed signals cancel the crosstalk components, not by switching the composite signal, but only by attenuating the stereo composite signal in the preset quantity. Consequently, the attenuator for reducing the stereo composite signal can be provided separately from the switching circuit for the stereo demodulation. The switching circuit can then be driven by the entire power supply voltage without any DC potential loss caused by the attenuator. Moreover, there is no DC potential loss by the attenuator, and transistors of the stereo switching circuit can operate with a power voltage margin. The distortion-free dynamic range of the output can be widened and the separation factor can be enhanced. The bias voltage of the active elements is also raised, so that the distortion factor characteristics can be improved. The composite signal attenuated in the preset quantity is superimposed upon the demodulated left and right signal components. Thus, it is possible to eliminate the distortion in the attenuated composite signal, and especially to eliminate the distortion in the demodulated output signals.

Stereo signal demodulator having an improved separation characteristic

A semiconductor chip contains a multi-channel signal-processing circuit for processing signals in different frequency bands (e.g., an AM and an FM receiver). An inductor is coupled via an external terminal on a package for the semiconductor chip to a first signal-processing circuit. A circuit detects when a connection is made between the inductor and a power supply terminal contained in the semiconductor chip. When the inductor is connected to the power supply terminals, the first signal-processing circuit is activated, while the second signal-processing circuit is deactivated. When the inductor is disconnected from the power supply terminal, the second signal-processing circuit is activated, while the first signal-processing circuit is deactivated. The circuit for detecting a connection between the inductor and the power supply terminal is either a circuit for detecting a potential change or a circuit for detecting an oscillating signal. The inductor may be either an oscillator coil or an IF transformer winding.

Growing community of inventors

Tokyo, Japan

Kazuyuki Doi