Otsuka Pharmaceutical Company, Limited

Kazuyoshi Kawai

Satoru Nakai

Yoshikatsu Hirai

Mayumi Kaneta

Yasuo Yanagihara

Yeong-Man Hong

Setsuko Takegata

Yoshikazu Kikumoto

Kiyoshi Ishii

Koutoku Aihara

Michiaki Tominaga

Hideo Tanaka

Masakazu Adachi

Seiji Akamatsu

Hiroyuki Ichikawa

Fumio Saito

Takashi Kamogashira

Yoshihiro Masui

Hitomi Iba

Yasue Konishi

A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.

IL-1.beta. and derivatives thereof and drugs

This invention provides an anti-tumor agent and a method for treating a tumor wherein gamma-interferon and interleukin-1 are used as active ingredients.

Method of treating colon, renal, and lung carcinomas with

DNA encoding interleukin IL-1.beta. mutant

The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

IL-1.alpha. derivatives

Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.

Methods of use of IL-1.alpha.

Apoptosis regulating compositions each comprising a member selected from a series of carbostyril derivatives and salts thereof, inclusive of carbostyril derivatives of general formula (1) ##STR1## and salts thereof, as an active ingredient are provided. The apoptosis regulating compositions of the invention are of use as anticancer agents, antiretrovirus agents, therapeutic agents for autoimmune diseases, therapeutic agents for thrombocytopenia, therapeutic agents for Alzheimer's disease, therapeutic agents for diseases of the liver, and cancer metastasis inhibitors, among others.

Apoptosis regulating composition

Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.

Method and use of IL-1.alpha.

An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..

Gene that encodes for polypeptides of IL-1.alpha.

The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.

IL-1.alpha. derivatives and medicament for treating thrombocytopenia

IL-1.alpha. derivatives and drugs

This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. ##STR1## wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence ##STR2## or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.

Growing community of inventors

Tokushima-ken, Japan

Kazuyoshi Kawai