Takeda Chemical Industries, Inc.

Kazuyoshi Katamoto

Kiyoshi Nara

Takashi Suzuki

Kazuaki Kitano

Hidekazu Sawada

Kazuhiko Kintaka

Kazuhiko Ohta

Yoshio Nakao

Sadao Ohkido

Isao Yamamoto

Hiroshi Yanome

Shigeru Suzuki

The interseparating of desacetyl-cephalosporin C, desacetoxy-cephalosporin C and cephalosporin C can be accomplished by adsorbing these available cephalosporins on activated carbon and effecting a fractional elution thereof with water containing 0 to 20 percent (V/V) of an organic solvent or solvents.

Method for separating cephalosporins

The present invention relates to a method for concentrating a dilute aqueous solution of a .beta.-lactam antibiotic which is readily susceptible to heat, by subjecting a dilute aqueous solution of a .beta.-lactam antibiotic, said solution containing 2 to 20% (v/v) of a lower alcohol, to concentration by means of a permeable membrane made of poly(ether/amide) or polybenzimidazolone.

Method for concentrating .beta.-lactam antibiotic solution

Mildiomycin analogs and a method of production

Deacetoxycephalosporin C can be produced with advantage by fermentation of a microorganism which belongs to the genus Streptomyces, Cephalosporium, Emericellopsis, Paecilomyces, Anixiopsis, Arachnomyces or Spriroidium and is capable of producing deacetoxycephalosporin C. Deacetoxycephalosporin C is a useful antibiotic as such or can be used as a starting material for the production of other various cephalosporin antibiotics.

Production of deacetoxycephalosporin C

Growing community of inventors

Suita, Japan

Kazuyoshi Katamoto