Fujisawa Pharmaceutical Company, Ltd.

Kazuyoshi Jomon

Tadaaki Komori

Masaru Kurita

Isami Nakatani

Ikuo Ueda

Hiroshi Imanaka

Daizou Morino

Masahiro Tsuji

Junzi Hosoda

Heiichi Sakai

Production of antibiotic WS-3442 A, B, C, D and E, and their acyl derivatives thereof, the production of antibiotic WS-3442 A, B, C, D and E being a new method by culturing a new species of Streptomyces and their acyl derivatives of said antibiotics being prepared by acylating said antibiotics with an acylating agent. The acyl derivative of antibiotic WS-3442 A, B, C, D and E has antimicrobiological activity and is also useful for intermediate for preparing Cephalosporin derivatives having antimicrobiological activity.

Production of antibiotics WS-3442 A, B, C, D and E, and their acyl

Purification of Fr-1923 antibiotic substance by treatment with a macroporous non-ionic adsorption resin such as styrene-divinyl benzene copolymer or acrylic ester polymer.

Process for the purification of FR-1923 substance

A process for the purification of bicyclomycin by treating a solution thereof with a macroporous nonionic adsorption resin.

Process for the purification of bicyclomycin

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Kawanishi, Japan

Kazuyoshi Jomon