Kaken Chemical Co., Ltd.

University of Illinois

Kazuya Sasaki

Kenneth L Rinehart

Frederick J Antosz

Yukio Inoue

Kazukiyo Onodera

Toshiyuki Satomi

Toshio Sega

Takanobu Naito

Yoshio Momoki

Hiromi Mitsui

Geldanamycin derivatives the following formula ##STR1## wherein R.sup.1 represents a saturated alkylamino which should have at least two carbon atoms, an unsaturated alkylamino, a substituted lower alkylamino, cycloalkylamino, pyrrolidino or aralkylamino group or methoxy group; R.sup.2 represents hydrogen atom, a halogen atom or a lower mono or dialkylamino; when R.sup.1 is methoxy group, R.sup.2 is a halogen atom or lower alkylamino group, or ##STR2## and Geldanamycin derivative is 8,9-epoxy-Geldanamycin. The compounds are effective as antitumor drugs.

Geldanamycin derivatives and antitumor drug

Streptovaricin C derivatives having the formula ##STR1## wherein R represents an allyl, cycloalkyl or adamanthyl group or a C.sub.1 -C.sub.20 alkyl group which can be substituted with hydroxyl, cyano, acetyl, formyl, furoyl, thenoyl, alkoxy, carbamyl, phenyl or substituted phenyl group or a phenacyl group which can be substituted with a halogen, alkoxy or phenyl group.

Streptovaricin C derivatives

New biologically active compounds derived by acylation and/or oxidative degradation of streptovaricin ansamycin materials, pharmaceutical compositions and therapeutic methods involving the same.

Derivatives of streptovaricin ansamycins

Streptovaricinone C derivatives of the formula ##STR1## wherein Z is a C.sub.1.sub.-12 alkyl, an aryl, a hydroxyalkyl, an alkenyl, a ketonyl, a furyl-oxoalkyl, a thienyl-oxoalkyl, a phenacyl, a carbamylalkyl, a benzyl, a phenoxyalkyl, a cyanoalkyl, a phenethyl, a benzoyloxyethyl, a p-chlorophenacyl, a p-methoxyphenacyl, a p-nitrobenzyl, a p-methylbenzyl, an alkanoyl, a benzoyl, a benzenesulfonyl, an alkylsulfonyl or an alkoxycarbonyl group, are antibiotics.

Streptovaricinone C derivatives as antibiotics

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Higashikurume, Japan

Kazuya Sasaki