Mitsui Toatsu Chemicals, Incorporated

Mitsui Chemicals, Inc.

Kazuya Sakai

Akira Matsubara

Hideki Tanada

Kazutoshi Horikomi

Akira Mizuchi

Seitaro Kajiya

Norio Ohto

Hideshi Shimizu

Hajime Iizuka

Hironori Komatsu

Yoshinori Tanaka

Yuji Enomoto

Takahisa Oguchi

Koichi Takeuchi

Hitoshi Shimotori

Yoshikata Hojo

Shunichi Inami

Hidetoshi Tsunoda

Michiru Sekiguchi

Hiroshi Nagase

Naruyoshi Mita

Shiro Takagi

Toshiyuki Kouno

Takaichi Miwa

Junya Fujiwara

Kenji Kibayashi

Fumiki Shimada

Yoshio Shiga

Takuma Ohtsu

Shinji Takahashi

Mithuo Itakura

Masahiro Sakakibara

Pyrazoline derivative or tetrahydropyridazine derivative and medicinal use thereof

Amino acid N-carboxyanhydrides with acyl substituents on nitrogen atoms thereof

Since a compound represented by general formula (1), its pharmaceutically acceptable salt and a hydrate of the pharmaceutically acceptable salt have high antipsychotic activity, they may be used as an active ingredient for preparation of an antipsychotic. ##STR1## Also provided are an optical resolution method of the above compound and an intermediate for preparation of the compound.

Pyrrolidinone derivatives

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl] isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivatives and use thereof

Aminoketone derivative compounds containing a heterocyclic ring bonded to an aminoketone moiety and useful as effective ingredients of centrally acting muscle relaxants and pollakiurea curing agents. (+)3-phenyl-5-[2-(1-pyrrolidinylmethyl)butyryl]isoxazole, which has a more remarkable central muscle relaxant action as compared with its racemic modification, can be effectively separated from the racemic modification using optically active 10-camphorsulfonic acid as the agent for the optical resolution.

Aminoketone derivative and use thereof

Aminoketone derivatives of 1,2-oxazole and use thereof

Novel aminoketones useful as central muscle relaxants and their preparation processes are disclosed. The disclosed processes are novel processes which do not use any heavy metal in view of the facts that their products are will be used as drugs and which require no complex purification step such as liberation of the aminoketones from their hydrochlorides or the like.

Preparation process of aminoketones

Described herein are imidazole derivatives having a specific structure and satisfactory as antiepileptics from the standpoint of the strength of action, prolonged action and side effects as well as their preparation processes.

Imidazole derivatives and antiepileptics comprising said imidazole

Substituted propargyloxyacetonitrile derivative represented by the general formula (I) ##STR1## wherein R represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group, a lower alkoxy group, a methylenedioxy group, a nitro group or a cyano group, n represents an integer of 1 to 5 and when n is an integer of 2 or more, R's may be identical or different, R.sup.1 represents a hydrogen atom or a lower alkyl group, and R.sup.2 represents a hydrogen atom, a lower alkyl group, a lower haloalkyl group or a halogen atom, provided that R.sup.1 and R.sup.2 are not simultaneously hydrogen atoms. The compounds have herbicidal and fungicidal activities.

Substituted propargyloxyacetonitrile derivatives, process for production

Growing community of inventors

Mobara, Japan

Kazuya Sakai