Daiichi Sankyo Company, Limited

Kazutoshi Ukai

Masaki Hayashi

Yoshitaka Nakamura

Yutaka Kitagawa

Tsuyoshi Ueda

Makoto Imai

Takafumi Kitawaki

Masakazu Wakayama

Yukito Furuya

Eiji Numagami

Takumi Nakajima

Ayako Saito

A method for producing a compound (4), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst. 

Methods for producing optically active valeric acid derivatives

A method for producing a compound (3), which comprises allowing a compound (1) to react with hydrogen gas in an inert solvent, in the presence of a specific chiral ligand and a ruthenium catalyst, or in the presence of an asymmetric transition metal complex catalyst previously generated from the chiral ligand and the ruthenium catalyst. 

An object of the present invention is to provide an optically active bicyclic &#x3b3;-amino acid derivative in a high purity. The object can be attained by a mixture of compounds represented by the general formulas (I) and (I'), or a method for producing a compound represented by the general formula (VII) or a salt thereof via the compound (I): wherein Rand Reach represent a C1-6 alkyl group or the like; and Rrepresents a cyano group or the like, 

Preparation method for optically active bicyclic gamma-amino acid compound

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Kanagawa, Japan

Kazutoshi Ukai