Fujisawa Pharmaceutical Company, Ltd.

Kazutoshi Sakamoto

Seiji Hashimoto

Satoshi Ueda

Michio Yamashita

Masami Ezaki

Masaru Tsuboi

Miho Tanaka

Nobutaka Oohata

Shigehiro Takase

Kohji Kawabata

Hiroshi Hatanaka

Yasuhisa Tsurumi

Hidenori Ohki

Keiji Matsuda

Yasuhiro Hori

Motohiro Hino

Takashi Tojo

Michizane Hashimoto

Nobuyuki Shiraishi

Ryuichi Kanasaki

Hiroaki Mori

Cyclic lipopeptide acylase

A cyclic tetrapeptide compound and use thereof. Especially, a compound WF27082, a process for production of the compound by culturing, in a nutrient medium, a WF27082-producing strain belonging to Acremonium and recovering the compound from a culture broth, a pharmaceutical composition containing the compound as an active ingredient, in association with a pharmaceutically acceptable, substantially non-toxic carrier or excipient, the compound for use as a medicament, a use of the compound for manufacture of a medicament for inhibiting histone deacetylase, a use of the compound for manufacture of a medicament for treating or preventing inflammatory disorders, diabetes, diabetic complications, homozygous thalassemia, fibrosis, cirrhosis, acute promyelocytic leukaemia (APL), protozoal infections, organ transplant rejections, autoimmune diseases, or tumors, a use of histone deacetylase inhibitors as an immunosuppressant or an antitumor agent, and a use of histone deacetylase inhibitors for manufacture of a medicament for treating or preventing organ transplant rejections, autoimmune diseases or tumors are described.

Cyclic tetrapeptide compound and use thereof

Process for the deacylation of cyclic lipopeptides

Cyclic hexapeptides having antibiotic activity

The invention relates to new polypeptide compounds represented by the following formula &lsqb;I&rsqb;:

Echinocandine derivatives with antimicrobial activity

There is provided a cyclic lipopeptide acylase which is capable of deacylating the acyl side chain of a cyclic lipopeptide compound, e.g. Substance FR901379 or its analog, of the general formula &lsqb;I&rsqb; with effectiveness as well a method of producing a cyclic peptide compound which comprises using the acylase.

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Tsuchiura, Japan

Kazutoshi Sakamoto