Taisho Pharmaceutical Co., Ltd.

Kazutoshi Mizoue

Sadafumi Omura

Haruo Seto

Noboru Otake

Michio Yamagishi

Taku Mizutani

Akira Kawashima

Hiroshi Hara

Joji Sasaki

Takashi Adachi

Shigeo Morimoto

Kazunori Hanada

Takatoshi Nagate

Tadayasu Okazaki

Toshiro Amamoto

Akiko Mikami

Mucor circinelloides f. griseo-cyanus IFO 4563 is cultivated in a medium containing 6-O-methylerythromycin A as a substrate to obtain 14-hydroxy-6-O-methyl-erythromycin A. This compound and its salt have anti-bacterial activity.

Process for preparing 14-hydroxy-6-O-methyl-erythromycin A

Tripeptide derivatives of the formula ##STR1## wherein R is a formyl group or a dimethoxymethyl group have antitumor and enzyme inhibition effects.

Novel tripetide derivatives

A method for introducing hydroxyl groups into vitamin D compounds at 1.alpha.- and/or 25-positions by use of a solution containing the mycelium of Actinomycetales being capable of hydroxylating vitamin D compound or the enzyme produced from the mycelium, is disclosed.

Method for preparing vitamin D compounds

A novel compound of the formula ##STR1## and the salts thereof, derived from dianemycin, are useful as antiprotozoal and antibacterial agents.

Novel dianemycin derivative

The novel antibiotics represented by the formula ##STR1## wherein either (a) R.sup.1 is hydroxy and R.sup.2 is hydrogen, or (b) R.sup.1 is methoxy and R.sup.2 is hydroxy, and the salt thereof, are produced by the cultivation of the organism Streptomyces hygroscopicus TM-531 under aerobic conditions. They are separated from coproduced Antibiotic TM-531 as disclosed in U.S. Pat. No. 4,269,971 and from each other by chromatography on silica gel.

Antibiotics TM-531 B and TM-531 C

Antibiotic TM-531 having the formula: ##STR1## TM-531 is effective against gram-positive bacteria, plant pathogenic microorganisms and protozoa.

Antibiotic TM-531

Novel lonomycin derivatives, prepared by reacting lonomycin or its salt with an alkali or an alkali metal borohydride, show antibacterial, antiviral and antiprotozoal activity, and have decreased toxicity as compared with lonomycin.

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Urawa, Japan

Kazutoshi Mizoue