Mitsubishi Gas Chemical Company, Inc.

Saitama University

Nagoya University

Kazuto Ikemoto

Hitoshi Sakamoto

Masahiko Nakano

Hajime Shimizu

Tetsuo Aoyama

Tatsuya Hasegawa

Taketo Maruyama

Junichi Edahiro

Kanako Koike

Yoshiaki Yamamoto

Hiroshi Yoshida

Takafumi Abe

Yoshikazu Shima

Hirofumi Higuchi

Takako Uchiyama

Kojiro Abe

Hisaki Abe

Satoko Imaruoka

Ichiro Sakata

Takafumi Sakai

Satoshi Sakahara

Yusuke Okubo

Sayaka Aizawa

Ikue Mori

Takafumi Skai

Hiroyuki Sasakura

Toshiyuki Gotoh

Tsuyoshi Mikekado

Nur Syafiqah Mohamad Ishak

Atsushi Sugimoto

Provided is a solubilization enhancer for pyrroloquinoline quinone or a salt thereof in an aqueous solvent, comprising resistant dextrin as an active ingredient.

Solubilization enhancer for pyrroloquinoline quinone, composition comprising same and method for enhancing solubilization

An analysis method having: a sample preparation step of preparing a measurement sample by mixing a measurement object containing pyrroloquinoline quinone or a salt thereof with glycine so that the pyrroloquinoline quinone or the salt thereof reacts with the glycine to produce imidazopyrroloquinoline or a salt thereof; and a quantitative analysis step of determining quantitatively the amount of the pyrroloquinoline quinone and the salt thereof contained in the measurement object, based on a chromatogram of the imidazopyrroloquinoline or the salt thereof contained in the measurement sample obtained by chromatography.

Analysis method

The present invention provides pyrroloquinoline quinone monosodium having a structure represented by the following formula (1). 

Pyrroloquinoline quinone monosodium and method for producing the same, and composition comprising the same

The present invention provides a method of inducing autophagy, the method including administering to a subject an effective amount of a pyrroloquinoline quinone compound or a salt thereof.

Method of inducing autophagy

There are provided an alkali metal salt of 5-hydroxy-4-oxo-5-(2-oxopropyl)-4,5-dihydro-1H-pyrrolo[2,3-f]quinoline-2,7,9-tricarboxylic acid, a method for producing the alkali metal salt, and a cocrystal comprising the alkali metal salt.

High-solubility acetone-added pyrroloquinoline quinone salt

There is provided a production method for the purpose of improving the solubility of an arginine-residue imidazopyrroloquinoline in water and making the purity thereof high. There is provided a compound represented by general formula (1): wherein n is 1, 2, 3 or 4; and M is an alkali metal or ammonium.

Imidazopyrroloquinoline salt, method for producing the same, medicament, cosmetic, and food

The present invention provides a life-extending agent comprising pyrroloquinoline quinone and/or a derivative of the pyrroloquinoline quinone.

Life-extending agent, life extension method using the life-extending agent, novel dual oxidase activator, method for activating dual oxidase, production of life-extending agent, and production of dual oxidase activator

A yellow reduced pyrroloquinoline quinone crystal having a solubility in water of 0.040 to 0.20 (mg/mL).

Yellow reduced pyrroloquinoline quinone crystal and method of producing the same, and food, pharmaceutical, gel, composition and method of producing composition

The present invention relates to a compound represented by the formula (A) or (B), or a salt thereof capable of improving a red color of pyrroloquinoline quinone (PQQ) and obtaining functions of original PQQ, and to a method of efficiently manufacturing the compound. wherein R is an alkyl group, a hydroxyalkyl group, a dihydroxyalkyl group, or an alkoxyalkyl group.

Pyrroloquinoline quinone alcohol adduct

An object of the present invention is to provide a pyrroloquinoline quinone tetraalkali salt needing no special reagent, having a high solubility in a solvent, being capable of providing a high-concentration pyrroloquinoline quinone aqueous solution, being hardly changed in color even if being concurrently used with ascorbic acid, and being of a high quality and a high purity; a crystal of a pyrroloquinoline quinone tetrasodium salt; a composition; and a simple method for producing the pyrroloquinoline quinone tetraalkali salt. The pyrroloquinoline quinone tetraalkali salt is represented by the formula (1): wherein M is each independently one selected from the group consisting of Li, K, Na, Rb and Cs.

Pyrroloquinoline quinone tetraalkali salt and crystal thereof, methods for producing these, and composition

A crystal of pyrroloquinoline quinone disodium salt having peaks at 2&#x3b8; of 9.1&#xb0;, 10.3&#xb0;, 13.8&#xb0;, 17.7&#xb0;, 18.3&#xb0;, 24.0&#xb0;, 27.4&#xb0;, 31.2&#xb0; and 39.5&#xb0; (&#xb1;0.2&#xb0; for each) in powder X-ray diffractometry using Cu K&#x3b1; radiation, or a crystal of pyrroloquinoline quinone trisodium salt having peaks at 2&#x3b8; of 6.6&#xb0;, 11.4&#xb0;, 13.0&#xb0;, 22.6&#xb0;, 26.9&#xb0;, 27.9&#xb0;, 37.0&#xb0;, 38.9&#xb0; and 43.4&#xb0; (&#xb1;0.2&#xb0; for each) in powder X-ray diffractometry using Cu K&#x3b1; radiation.

Crystals of pyrroloquinolinequinone sodium salts

An object of the present invention is to provide a novel pyrroloquinoline quinone disodium crystal having excellent dispersibility in solvents and excellent permeability through skin, and a method for producing the pyrroloquinoline quinone disodium crystal with high efficiency. According to the present invention, provided are a novel pyrroloquinoline quinone disodium crystal which is produced by drying a crystal produced under specified conditions through a drying means such as lyophilization, ambient drying and vacuum drying, and a method for producing the pyrroloquinoline quinone disodium crystal.

Pyrroloquinoline quinone disodium salt crystal and method for producing the same

An object of the present invention is to provide a gel containing pyrroloquinoline quinone that is capable of easily forming a gel near room temperature and is useful even in the food sector, and a method for producing the gel. According to the present invention, there is provided a gel containing pyrroloquinoline quinone that uses pyrroloquinoline quinone itself as a gelling agent and a method for producing the gel by adding a salt of pyrroloquinoline quinone to water and subsequently adjusting the temperature or the pH to reduce solubility.

Pyrroloquinoline quinone gel

An object of the present invention is to provide an industrially useful method for producing a calcium salt of pyrroloquinoline quinone, without using large amounts of organic solvents, and highly pure crystals produced thereby. According to the present invention, a highly pure calcium salt of pyrroloquinoline quinone can be produced by reacting an alkali metal salt of pyrroloquinoline quinone with a source of calcium ions.

Growing community of inventors

Niigata, Japan

Kazuto Ikemoto