Hoffmann-la Roche Inc.

Kazuteru Yokose

Yasuji Suhara

Nobuo Shimma

Tatsuo Ohtsuka

Hiromi Maruyama

Masahiro Aoki

Morio Fujiu

Kimihiro Watanabe

Kiyoshi Ogawa

Isao Umeda

Hideo Ishitsuka

Masanori Miwa

Miyako Kamata

Toyoaki Sawada

Mayumi Ogawa

Sayuri Itoh

Mikayo Kamata

The novel 5'-deoxy-5-fluorocytidine derivatives of formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are hydrogen or an easily hydrolyzable radical under physiological conditions, with the proviso that, at least one or R.sup.1, R.sup.2 and R.sup.3 is an easily hydrolyzable radical under physiological conditions, as well as hydrates of solvates of these compounds have antitumor properties. They can be prepared from compounds of formula I, wherein R.sup.1 is hydrogen or an amino-protecting radical and R.sup.2 and R.sup.3 are hydrogen or a hydroxy-protecting radical or taken together are a cyclic hydroxy-protecting radical.

Fluorocytidine derivatives

The invention is concerned with tricyclic compounds of the formula ##STR1## wherein R.sup.1 is a hydrogen atom or a carboxy-protecting radical; R.sup.2 is a hydrogen atom or a lower alkyl radical which may be substituted with a halogen atom; R.sup.3 and R.sup.4 independently are a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical or a substituted or unsubstituted amino radical; X is a halogen atom; and R.sup.5 and R.sup.6 are independently a hydrogen atom or a lower alkyl radical which may be substituted with a hydroxy radical, a lower alkoxy radical or a substituted or unsubstituted amino radical; or R.sup.5 and R.sup.6, taken together with the adjacent nitrogen atom, may form a 5 to 7 membered heterocyclic ring which may be substituted with one or more substituents at the carbon atom(s), and the heterocyclic ring may further contain --NR.sup.7 --, --O--, --S--, --SO--, --SO.sub.2 -- or --NR.sup.7 --CO--, and also R.sup.7 is a hydrogen atom, a lower alkenyl radical, a lower alkyl or aralkyl radical which may be substituted, or a radical represented by the formula

Pyrido(3,2,1-IJ)-1,3,4-benzoxadiazine derivatives

Pyrido(3,2,1-IJ)-1,3,4 benzoxadiazine derivatives

This invention relates to Trestatin A, Trestatin B and Trestatin C salts thereof and mixtures thereof as well as compositions containing at least one of the Trestatins A, B or C or a salt thereof. These compositions are useful for the inhibition of sucrase and inhibition of alpha-amylase.

Amino sugar derivatives containing trehalose

The present invention is concerned with a process for the manufacture of optically active .alpha.-hydroxycarboxylic acids, especially a process for the manufacture of optically pure D- or L-.alpha.-hydroxycarboxylic acids.

Process for the manufacture of optically active

A process for the resolution of a racemate, namely of DL-N-benzyloxycarbonyl-2-(p-hydroxyphenyl)-glycine.

Resolution of a racemate

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Urayasu, Japan

Kazuteru Yokose