Wako Pure Chemical Industries, Inc.

Fujifilm Corporation

Kazushige Muto

Tsuneaki Maesawa

Nobuhiro Ito

Hironao Sajiki

Kosaku Hirota

Hiroki Sasaki

Kazuhiro Kato

Masahiro Sogo

The subject of the present invention is to provide a method for deuteration, which can obtain a compound having an aromatic ring and/or a heterocyclic ring at an improved deuteration ratio. The present invention relates to a method for deuteration of a compound having an aromatic ring and/or a heterocyclic ring, comprising reacting the compound having an aromatic ring and/or a heterocyclic ring with a heavy hydrogen source in the presence of an activated mixed catalyst of not less than two kinds of catalysts selected from among a palladium catalyst, a platinum catalyst, a rhodium catalyst, an iridium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.

Method of deuteration using mixed catalyst

The present invention relates to a method for deuteration of a compound having an aromatic ring, using an activated catalyst, and the method comprises reacting a compound having an aromatic ring with heavy hydrogen source in the presence of an activated catalyst selected from a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst.

Method for deuteration of an aromatic ring

The present invention relates to a method for deuteration of a heterocyclic ring, which comprises subjecting a compound having a heterocyclic ring to sealed refluxing state in a deuterated solvent in the presence of an activated catalyst selected form a palladium catalyst, a platinum catalyst, a rhodium catalyst, a ruthenium catalyst, a nickel catalyst and a cobalt catalyst. In accordance with a method of the present invention, a hydrogen atom belonging to a heterocyclic ring of a compound having a heterocyclic ring can be very efficiently deuterated because temperature of deuteration reaction can be maintained at higher than boiling point of the solvent. Further, a method for deuteration of the present invention can be applied widely to deuteration of various compounds having a heterocyclic ring which are liable to decomposition under supercritical conditions or acidic conditions, leading to industrial and efficient deuteration of a compound having a heterocyclic ring.

Method for deuteration of a heterocyclic ring

A novel compound represented by a formula [1] wherein Rand Rrespectively represent a light or heavy hydrogen atom, Rrepresents a light or heavy hydrogen atom or a methyl group in which tree hydrogen atoms are respectively light or heavy hydrogen atoms, and Ris a norbornyl group provided that four or more hydrogen atoms in the norbornyl group are heavy hydrogen atoms; and a novel polymer produced by polymerization of a composition comprising the compound are disclosed. 

Heavy-hydrogenated norbornyl (meth)acrylates, process for producing them, polymers thereof and optical members

A block copolymer comprising siloxane segments, amphoteric monomer units and/or cationic nonomer units, and if necessary monomer units of precursors thereof, and nonionic monomer units, obtained by polymerization in the presence of a special azo group-containing polysiloxane compound is useful as paint resins, coating resins and base materials for hair cosmetics.

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Kawagoe, Japan

Kazushige Muto