Seiko Epson Corporation

Ss Pharmaceutical Co., Ltd.

Kazuo Uebaba

Kazuhiko Amano

Hitoshi Ishiyama

Hiroshi Kasahara

Fumitake Shimada

Tetsuro Ikekawa

Jong-Chol Cyong

The present invention relates to a device for diagnosing physiological state based on blood pulse waves detected in the body. It is the objective of the present invention to provide a device which correctly diagnoses the current physiological state based on changes in physiological state measured over a specified period of time in the past while taking into consideration the cyclical variation exhibited in physiological state. In order to realize this objective, the device according to the present invention has as its main components: blood pulse wave detectorand stroke-volume-per-beat measurerwhich respectively detect blood pulse wave and stroke volume in the body; blood pulse wave extraction memorywhich extracts characteristic information from the detected blood pulse wave; memoryin which the physiological state calculated from the stroke volume and this characteristic information is stored; output portionwhich outputs an alarm; and microcomputerwhich controls each part inside the device. The microcomputer calculates the circulatory parameters based on characteristic information obtained from the waveform extraction memory, and stores the parameters in memory at specified time intervals. At these times, microcomputercalculates the circulatory parameters from the stroke volume per beat and the characteristic information of the blood pulse wave at specified time intervals, and stores the parameters in memory. Further, microcomputerreads out from memorythe circulatory parameters from a specified time interval in the past, and calculates the average value and standard deviation. Microcomputerthen determines whether or not the current circulatory parameters are within a specified range determined by their average value and standard deviation. When the circulatory parameters are determined to be outside this range, microcomputercontrols output portionto sound an alarm.

Device for diagnosing physiological state and device for controlling the same

In order to enable a user to easily and quickly ascertain his body's state of relaxation, the device is provided with: a physiological information extractor for extracting an indicator expressing physiological state from user Y; a storage member for storing the extracted indicator; a judging member for analyzing the change over time in the stored indicator, and determining whether or not the user's condition has improved toward a state of greater relaxation based on the indicator; and a notifying member for providing notice that the body has moved toward a state of greater relaxation, if the results of the aforementioned determination are affirmative.

Relaxation guidance device and biofeedback guidance device

When pulse waveform MH is detected by pulse wave detection sensor unit wavelet transformer performs wavelet transformation on pulse waveform MH and generates analyzed pulse wave data MKD. This analyzed pulse wave data MKD consists of a time region in which one heartbeat is divided into eighths, and the frequency region of 0-4 Hz which has been divided into eighths. Frequency corrector generates corrected pulse wave data MKD&prime; by performing frequency correction on analyzed pulse wave data MKD. Pulse type data generator compares corrected pulse wave data MKD&prime; over each frequency-time region, and generates pulse type data ZD indicating the type of pulse. Display displays the pulse type for pulse waveform MH based on pulse type data ZD.

Pulse wave diagnosing device

An optical type pulse wave detection section 1 detects the pulse waveform MH above the skin while moving in the circumferential direction of the arm, when a manual position change mechanism is operated. Capillary vessels and arterioles surrounding a radial artery are formed inside the skin, and pulsation of the capillary vessels and arterioles are opposite in polarity. When a polarity detection section outputs a polarity detection signal KS showing the polarity of the pulse waveform MH, the polarity is displayed on a display . Accordingly, a subject can position the pulse wave detection section above the arterioles surrounding the artery by operating the manual position change mechanism while observing the display , allowing the pulse waveform MH to be detected with an optimal SN ratio. In addition, the pulse waveform of the arterioles can be detected by specifying the position of the artery without causing a constrictive feeling to the subject.

Method of detecting pulse wave, method of detecting artery position, and pulse wave detecting apparatus

A non-invasive device for evaluating circulatory state parameters, and specifically, a pulsewave analysis device capable of evaluation by separating blood vessel compliance and blood vessel resistance into central and peripheral components of the arterial system is provided. Microcomputer,detects the waveform at a test subject's radius artery via pulsewave detector,and uptakes the stroke volume in the test subject which is measured by a stroke-volume measurer. Next, based on the measured stroke volume, microcomputer,adjusts the values of each element in a lumped five parameter model made up of an electrical circuit which models the arterial system from the center to the periphery of the body, so that the response waveform obtained when an electric signal corresponding to the pressure waveform at the proximal portion of the aorta in a test subject is provided to the electric circuit coincides with the waveform at the radius artery. Microcomputer,then outputs the thus-obtained values of each element as circulatory state parameters. In addition, microcomputer,calculates the diastolic pressure value, systolic pressure value and pulse waveform at the proximal portion of the aorta from the values of each element, and outputs the calculated result to output device

Device for measuring physiological state

An FFT treating section (,) carries out the frequency analysis of a pulse waveform MHj excluding a body movement component to yield pulse wave analysis data MKD and then a tidal wave-character extracting section (,) and a dicrotic wave-character extracting section (,) yield a tidal wave-character data (TWD) and a dicrotic wave-character data (DWD) showing the characteristics of a tidal wave and dicrotic wave respectively. Then, a pulse condition judging section (,) yields pulse condition data (ZD) on the basis of this data (TWD, DWD) and in succession a notifying section (,) advises of the pulse condition of a subject.

Pulse wave examination apparatus, blood pressure monitor, pulse waveform monitor, and pharmacological action monitor

In order to obtain calorie expenditure with good accuracy, the device is provided with a basal metabolic state specifying element (,) which specifies the subject's basal metabolic state from his body temperature; a correlation storing element (,) which stores respective regression formulas showing the correlation between the pulse rate and the calorie expenditure when the subject is at rest or active; a correlation correcting element (,) which correcting the stored regression formulas using the basal metabolic state; a body motion determining element (,) which determines whether or not the subject is at rest; and a regression formula selecting element (,) which selects the regression formula which should be used in accordance with the results of this determination. The subject's pulse rate is applied in the selected regression formula, and the calorie expenditure corresponding to this pulse rate is calculated by calorie expenditure calculator (,).

Device for measuring calorie expenditure and device for measuring body temperature

A device is provided, which is capable of determining the maximum oxygen uptake quantity without the restriction of a large device or requiring troublesome operations to be carried out. The device displays the upper and lower limit values for the pulse rate corresponding to an appropriate exercise intensity, and realizes in a wireless manner by means of optical communications the sending and receiving of information such as pulse wave signals to and from an information processing device which processes pulse wave information. The device is provided with a pulse wave detector,for detecting the test subject s pulse waveform; an FFT processor,for determining the test subject s heartbeat rate from the pulse waveform; a body motion detector,for detecting body motion when the test subject is running; an FFT processor,for determining the pitch from body motion during running by the test subject; exercise intensity calculator,for determining pitch, the test subject s stride, and the exercise intensity from body motion during running; and a nomogram recorder,for recording the relationship indicated by an Astrand-Ryhming nomogram, and determining the maximum oxygen uptake quantity from the heart rate and exercise intensity. The obtained maximum oxygen uptake quantity is divided by the test subject s body weight, to calculate the maximum oxygen uptake quantity per unit body weight. Next, the maximum oxygen uptake quantity and pulse according to sex are determined, and the pulse rate is multiplied by the upper and lower limit value coefficients, to determine the upper limit value UL and the lower limit value LL for the pulse rate.

Exercise workout support device

A non-invasive device for evaluating circulatory state parameters, and specifically, a pulsewave analysis device capable of evaluation by separating blood vessel compliance and blood vessel resistance into central and peripheral components of the arterial system is provided. Microcomputer,detects the waveform at a test subject's radius artery via pulsewave detector,, and uptakes the stroke volume in the test subject which is measured by a stroke-volume measurer. Next, based on the measured stroke volume, microcomputer,adjusts the values of each element in a lumped five parameter model made up of an electrical circuit which models the arterial system from the center to the periphery of the body, so that the response waveform obtained when an electric signal corresponding to the pressure waveform at the proximal portion of the aorta in a test subject is provided to the electric circuit coincides with the waveform at the radius artery. Microcomputer,then outputs the thus-obtained values of each element as circulatory state parameters. In addition, microcomputer,calculates the diastolic pressure value, systolic pressure value and pulse waveform at the proximal portion of the aorta from the values of each element, and outputs the calculated result to output device

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Yokohama, Japan

Kazuo Uebaba