Other

Toudai Tlo, Ltd.

Sosei Co., Ltd.

Kazuo Shinya

Takashi Ono

Akihiro Tomida

Tohru Natsume

Takashi Tsuruo

Tetsuzo Tauchi

Takayuki Doi

Hae-Ryong Park

Toshiro Morohoshi

Disclosed is a labeling substance capable of reversibly immobilizing (reversible detachment) to a solid surface and to reliably and accurately identify a target biological substance interacting with a probe substance bound to the labeling substance. A chimeric compound is provided, which includes a labeling substance L including (1) an organic compound S with a chemical structure capable of binding to a probe substance P, which can interact with a biological substance B and (2) a peptide bound to the organic compound S and specifically recognized by an antibody A, peptide and a probe substance P at least except a peptide or protein. In addition, a method for preparing the labeling substance L and a method for capturing, structurally analyzing and/or identifying the biological substance using the labeling substance L are provided.

Labeling substance and chimeric substance and method for preparing the same and method for capturing, structurally analyzing and/or identifying biological substance by means of the labeling substance

An antitumor effect enhancer for enhancing the antitumor effects of an antitumor substance, which comprises a compound represented by the following formula (1): wherein each R independently represents a hydrogen atom, a lower alkyl group, an aryl group, an allyl group, an aralkyl group, a halogen atom, a hydroxyl group, an amino group, R'O&#x2014;, R&#x2032;(C&#x2550;O)&#x2014;, R&#x2032;(C&#x2550;O)O&#x2014;, or R&#x2032;O(C&#x2550;O)&#x2014;, wherein R&#x2032; is an alkyl group containing 1 to 5 carbon atoms, or a pharmaceutically acceptable salt thereof.

GM-95-containing antitumor effect potentiator, combined antitumor preparation and antitumor agent

The present inventors intended to search for substances that can regulate the expression of a molecular chaperone, GRP78, using the expression of GRP78 as an indicator. As a result, a novel tetronic acid derivative, versipelostatin compound (also known as JL68) shown in formula (I) having the activity of suppressing GRP78 expression was isolated from the metabolite ofstrain 4083-SVS6. Versipelostatin can be obtained from the culture supernatant by culturing the above-mentionedstrain 4083-SVS6 

Tetronic acid derivative

Growing community of inventors

Tokyo, Japan

Kazuo Shinya