Takara Shuzo Co., Inc.

Takara Bio Inc.

Other

Kazuo Shimanaka

Katsushige Ikai

Ikunoshin Kato

Takeshi Sakai

Kaoru Kojima

Kazutoh Takesako

Teruya Nakamura

Junko Yamamoto

Hideyo Yamaguchi

Fumiyo Haruna

Katsuhisa Uchida

Hitomi Kimura

Kaoru Katayama

Takanari Tominaga

Fu-Gong Yu

Yoshikuni Nakanishi

Takashi Kawai

Hideo Kitano

Hitomi Amarume

Shinji Nakayama

Naoyuki Awazu

Mitsuhiro Ueno

Kumiko Ishizuka

Three enzymes degrading sulfated glucuronofucan; processes for producing these enzymes; activators for these enzymes; glucuronofucan sulfate and degradation products thereof; and a novel microorganism.

Glucuronofucan sulfate

A smaller molecule obtainable by allowing a sulfated fucan-digesting enzyme which digests a novel sulfated polysaccharide derived from an alga belonging to Laminariales to act on a sulfated fucan, and a method for producing the same.

Sulfated fucan oligosaccharide

Apoptosis inducers, anticancer drugs and carcinostatic drugs containing sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof, and a method for inducing apoptosis by using sulfated-fucose-containing polysaccharide(s) and/or degradation product(s) thereof as the active ingredient. A degrading enzyme which is useful in the production of the degradation products of sulfated-fucose-containing polysaccharides.

Apoptosis inducers

Sulfated fucogalactan or its salt useful as a reagent for sugar chain engineering or an HGF-production inducer; a degraded product or its salt obtained by treating the sulfated fucogalactan with a sulfated fucogalactan digesting enzyme; the sulfated fucogalactan digesting enzyme useful in sugar chain engineering; a process for producing the degraded product by treating sulfated fucogalactan or its salt with the above enzyme; and a process for producing the sulfated fucogalactan digesting enzyme.

Sulfated fucogalactan

Antibiotic TKR459, production method, and microorganism

An antibiotic R106 represented by the general formula I): ##STR1## wherein: R is methyl or ethyl;

Aureobasidium pullulans which produces antibiotic R106

There are provided R106 compounds represented by the following general formula (I): ##STR1## wherein: A.sub.1 is Phe, o-FPhe, m-FPhe, or Tyr;

R106 compounds

An antibiotic R106 represented by the general formula (I): ##STR1## wherein: R is methyl or ethyl;

Process for the production of antibiotic R106 by a strain of

Novel antibiotics R106

Growing community of inventors

Takatsuki, Japan

Kazuo Shimanaka