Fujisawa Pharmaceutical Company, Ltd.

Nippon Shokubai Co., Ltd.

Wakunaga Pharmaceutical Co., Ltd.

Kazuo Sakane

Jiro Goto

Tsutomu Toyonaka Teraji

Kohji Kawabata

Kenzi Miyai

Takao Takaya

Takashi Kamiya

Yoshiharu Nakai

Yoshiko Inamoto

Hideaki Yamanaka

Shinya Okuda

Takeshi Terasawa

Kunihiko Tanaka

Yoshiki Yoshida

Yoshio Kawai

Masayoshi Murata

Masakuni Okuhara

Hiroshi Imanaka

Masanobu Kohsaka

Yoshinari Sato

Hideo Tsutsumi

Akira Yazaki

Michio Yamashita

Hiroyuki Setoi

Hitoshi Mitsui

Satoshi Inoue

Yasuhisa Tsurumi

Hidenori Ohki

Itsuo Uchida

Chiyoshi Kasahara

Nobuharu Shigematsu

Nobuyoshi Yasuda

Tadaaki Komori

Teruaki Matuo

Shintaro Nishimura

Motohiro Hino

Ikuyo Katsumi

Seiichiro Tabuchi

Akihiko Fujie

David Barrett

Kumiko Nitta

Toshiro Iwamoto

Junji Hosoda

Yuichi Satoh

Jiro Gotto

Benzodiazepine derivatives

The present invention relates to new cephem compounds, pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same and anti-bacterial methods of using the same. The subject cephem compounds comprise a thiadiazine ring bonded to the cephem through an iminoacetamido chain and a pyarzolium ring bonded to the cephem through a methylene chain.

Cephem compounds and processes for preparation thereof

Compounds of the formula: ##STR1## wherein R is a group of the formula: ##STR2## in which R.sup.3 and R.sup.4 are each lower alkyl or R.sup.3 and R.sup.4 are linked together to form C.sub.3 -C.sub.6 alkylene, A is lower alkylene, and R.sup.5 is hydroxy or a protected hydroxy group; or a group of the formula: ##STR3## in which R.sup.6 is lower alkyl, R.sup.7 and R.sup.8 are each hydroxy or a protected hydroxy group, and Y is N or CH, and salts thereof are intermediates for cephem compounds which show antimicrobial activities and which are useful in the treatment of microbial infections.

Intermediates for cephem compounds

Cephem compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

Cephem compounds

A polypeptide compound having antimicrobial activity of the following general formula: ##STR1## wherein R.sup.1 is hydrogen or acyl group, R.sup.2 is hydroxy or acyloxy,

Polypeptide compound and a process for preparation thereof

The invention relates to a compound of the formula: ##STR1## of antimicrobial activity.

Cephem compounds and pharmaceutically acceptable salts thereof

Certain tricyclic pyrido[3,2,1-ij]cinnoline-8-carboxylates, useful as

The invention relates to compounds, useful as intermediates in the preparation of products of antimicrobial activity, of the formula: ##STR1## wherein R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, protected hydroxy(lower)alkyl, amino(lower)alkyl, protected amino (lower) alkyl, carbamoyl)lower)alkyl, N,N-di(lower) alkylcarbamoyl(lower)alkyl or an amino protective group, and

Cephem compounds having the following formula are disclosed: ##STR1## R.sup.1 =amino or protected amino R.sup.2 =an organic group ##STR2## R.sup.6 =lower alkyl R.sup.7, R.sup.8 .dbd.OH or protected OH

Cephem compounds of the following formula are disclosed: ##STR1## wherein R.sup.1 is amino or protected amino group. R.sup.2 is H or an organic group,

The invention relates to compounds of antimicrobial activity, of the formula ##STR1## wherein R.sup.1 is amino or protected amino,

The invention relates to cephem compounds characterized by a substituted 2-pyrazolimethyl group and a 7-(aminothiazolyl) (hydroxyimino)-acetamido group and certain derivatives thereof, to pharmaceutical compositions comprising the same and to use for treatment of infectious diseases.

The invention relates to antimicrobial compounds of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino, R.sup.2 is ethyl, propyl or lower alkenyl,

Cephem compound

The invention relates to an antimicrobial compound of the formula: ##STR1## wherein R.sup.1 is amino or a protected amino group,

The invention relates to intermediate compounds of the formula: ##STR1## wherein R.sup.3 is a lower alkyl, hydroxy(lower)alkyl or a protected hydroxy(lower)alkyl,

Growing community of inventors

Amagasaki, Japan

Kazuo Sakane