Meiji Seika Kaisha, Ltd.

Kazuo Saito, Deceased

Shigeharu Inouye

Taro Niida

Takashi Shomura

Yasuaki Ogawa

Hiroshi Watanabe

Yujiro Yamada

Michio Kojima

Yasumitsu Kondo

Tomizo Niwa

Hitoshi Goi

A new antibiotic designated as SF-1623 substance exhibiting a useful antibacterial activity against gram-negative bacteria is now produced by cultivating a new strain ATCC 21999 of the known species Streptomyces chartreusis. The SF-1623 substance in the form of its an alkali metal salt may be recovered from the culture when the cultivation is effected under aerobic conditions in the presence of an alkali metal thiosulfate.

Antibiotic SF-1623 substance and the production thereof

Antibiotic SF-1623 substance

Novel 7-(5-amino-5-carboxyvaleramido)-7-methoxy-3-hydroxymethyl-3-cephem-4-carbo xylic acid derivatives. Such derivatives are prepared by subjecting cephamycin type compounds to the action of esterase enzyme of mold fungi.

Process for the production of cephamycin type antibiotic substances

Growing community of inventors

LATE OF Fujisawa, undefined

Kazuo Saito, Deceased