Eisai Company, Limited

Eisai R&d Management Co., Ltd.

Kazuo Okano

Shinya Abe

Isao Yamatsu

Hiroyuki Yoshimura

Koukichi Harada

Mitsuaki Miyamoto

Tetsuya Kawahara

Shuhei Miyazawa

Naoyuki Shimomura

Richard S Clark

Takeshi Suzuki

Shigeru Souda

Yoshimasa Machida

Kenzo Muramoto

Osamu Asano

Kouichi Katayama

Hironori Ikuta

Kenji Hayashi

Kouji Nakamoto

Youji Yamagishi

Kozo Akasaka

Tohru Fujimori

Kouji Yamada

Hiroshi Obaishi

Satoshi Katayama

Hajime Tsunoda

Yoshimori Sakuma

Tsutomu Kawata

Junsaku Nagaoka

Tsutomu Yoshimura

Hiromasa Suzuki

Fumihiro Ozaki

Takashi Inoue

Atsushi Kamada

Kenichi Chiba

Ryoichi Hashida

Toru Horie

Takashi Mori

Kenichi Kusube

Nobuaki Sato

Akiharu Kajiwara

Ieharu Hishinuma

Hiroshi Tanaka

Masanobu Shinoda

Fumiyoshi Matsuura

Itaru Tsukada

Makoto Kotake

Taro Terauchi

Hiroshi Shirota

Toshiyuki Matsuoka

Yoshimitsu Naoe

Shuichi Suzuki

Akifumi Kimura

Osamu Ito

Motoji Kogushi

Hiroko Kobayashi

Ken-ichi Chiba

Naoto Ono

Syuhei Miyazawa

Yoshiaki Oohashi

Toshihiko Kaneko

Norihito Ohi

Hiromitsu Yokohama

Takashi Musha

Tohru Arai

Masayoshi Ohkuro

Hirsohi Shirota

Richar S Clark

Takashi Musya

Naoyuki Kimomura

Tsutomu Kawada

Osamu Takenaka

Jiro Sonoda

Ken-Ichi Chiba

Keni-Ichi Chiba

Takashii Musha

A 2-iminoimidazole derivative represented by the formula: {wherein R, Rand Rrepresent hydrogen, optionally substituted Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2013;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc., and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocycle], etc.}or salt thereof.

2-iminoimidazole derivatives (2)

A 2-iminopyrrolidine derivative represented by the formula: {wherein ring B represents a benzene ring, pyridine ring, etc.; R&#x2013;Rrepresent hydrogen, halogen, Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkoxy-Calkyl, etc.; Rrepresents hydrogen, Calkyl, Calkyloxycarbonyl, etc.; Yrepresents a single bond, &#x2014;CH&#x2014;, etc.; Yrepresents a single bond, &#x2014;CO&#x2014;, etc.; and Ar represents hydrogen, a group represented by the formula: [wherein R&#x2014;Rrepresent hydrogen, Calkyl, hydroxyl, Calkoxy, etc.; and Rand Ror Rand Rmay bond together to form a 5- to 8-membered heterocyclic ring], etc.},or a salt thereof.

2-iminopyrrolidine derivatives

Benzopiperidine derivatives

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are useful in the pharmaceutical field, especially in treating allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

1,4-diazepine derivative and its pharmaceutical use

A glycerin derivative having the following formula (I) or (I') and a pharmacologically acceptable salt thereof are useful to treat diseases caused by the platelet activating factor. ##STR1##

Glycerin derivative and its pharmacological use

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OOO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to treat allergic diseases: ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

A triazolo-1,4-azepine compound of the below given formulas and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases. ##STR1## in which R1 and R2 are hydrogen or an alkyl, R3 is hydrogen or a halogen, R4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

Triazolo-1,4-diazepine derivatives and their use in pharmaceuticals

Compounds of the formula: ##STR1## where R.sup.1 is a hydrogen atom or a lower alkyl group;

Naphthalene derivatives

A triazolo-1,4-di-azepine compound of the below given formula and a pharmacologically acceptable salt thereof are disclosed and useful in the pharmaceutical field, especially to allergic diseases, ##STR1## in which R.sup.1 and R.sup.2 are hydrogen or an alkyl, R.sup.3 is hydrogen or a halogen, R.sup.4 is hydrogen or an alkyl, X is --OCO--, --NHCO--, --CO-- or others and Y is a cycloalkyl, a cycloalkylalkyl, an alkynyl or others.

The present invention relates to a naphthalene derivative. More particularly, it relates to a naphthalene derivative exhibiting an excellent activity as a drug.

Growing community of inventors

Ibaraki, Japan

Kazuo Okano