Taiho Pharmaceutical Company Limited

Taiho Pharmaceutical

Kazuo Ogawa

Setsuro Fujii

Ichiro Yamawaki

Yoshiyuki Muranaka

Toshihiro Hamakawa

Junji Yamamoto

Shingo Yano

Masato Nanri

Nobuo Kasahara

Manabu Kaneda

Takashi Arima

Takaji Honna

Sadao Hashimoto

Masakazu Fukushima

Tetsuhiko Shirasaka

Tomoyasu Ohno

Tetsuji Asao

Mitsugi Yasumoto

Yuji Yamada

Norio Unemi

Setsuo Takeda

Kiyoshi Eshima

Hiroyuki Kawamura

Shinichi Watanabe

Naohiko Ono

Yoshikazu Sugimoto

Yoh-ichi Matsushita

Toshiyuki Toko

Haruo Yamada

Sekio Nagayama

Shigeru Kaneko

Bicyclolactam compounds, use thereof and intermediates for preparing thereof

Bicycloloactam compounds, use thereof and intermediates for preparing thereof

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2##

Bicyclolactam compounds, use thereof and intermediates for preparing

A bicyclolactam compound of the formula (1) is disclosed, which has an excellent anxiolytic effect, is high in safety, and is useful as an effective component of medicinals which are greatly diminished in side effects such as hypnotic, muscle relaxant and sedative effects ##STR1## A bicyclolactam derivative represented by the following formula (1) is also disclosed, and is useful as an effective component of an anxiolytic agent ##STR2## .

This invention relates to a thiazolidinedione derivative represented by the following formula (1): ##STR1## wherein R.sup.1 and R.sup.2 individually represent H, a halogen atom, or a halogen-substituted or -unsubstituted lower alkyl or alkoxy group, and R.sup.1 and R.sup.2 may be coupled together to form a ring of an alkylenedioxy chain, X represents a nitrogen atom or a CH group, A represents a substituted or unsubstituted imidazolidinone, pyrrolidinone, imidazole or pyrazole ring, or a salt thereof; and a pharmaceutical composition containing the thiazolidinedione derivative or a salt thereof. The above compound has excellent blood sugar-lowering action and blood lipid-lowering action and is useful as a therapeutic agent for diabetes.

Thiazolidinedione derivatives or salts thereof and pharmaceutical

Thiazolidine derivatives and pharmaceutical compositions containing the

Oxazolidine derivatives and pharmaceutically acceptable salts thereof

1-phenylpyrrolidone derivatives having optical activity, intermediate

Benzothiadiazepine derivatives

1,1,2-triaryl-1-alkene derivatives

W-amino alkylsulfonate derivatives for improving microcirculation

A sulfonic acid ester derivative represented by the general formula ##STR1## wherein R.sub.1 is a hydrogen atom, alkyl having 1 to 4 carbon atoms or alkoxy having 1 to 4 carbon atoms, A is a group represented by the general formula ##STR2## (wherein R.sub.2 and R.sub.3 are each alkyl having 1 to 4 carbon atoms) or by the general formula ##STR3## (wherein R.sub.4 and R.sub.5 are each alkyl having 1 to 4 carbon atoms or, when taken together with the carbon atom to which they are attached, form cycloalkyl having 4 to 6 carbon atoms), and l is an integer of from 1 to 3, and a process for preparing the derivative.

Sulfonic acid ester derivatives and process for preparing same

Disclosed are a compound of the formula ##STR1## wherein R.sub.1 is lower alkyl, A is a group of the formula ##STR2## (in which R.sub.3 is hydrogen or lower alkyl) or methylene, and R.sub.2 is hydrogen or a group of the formula --(CH.sub.2).sub.n COOH (in which n is an integer of 1 to 6) or a salt of the derivative, and preparation thereof. The compounds have an excellent aldose reductase inhibitory action.

Rhodanine derivatives and process for preparing the same

A piperazine derivative represented by the formula (I) below ##STR1## wherein R.sup.1 is lower alkyl or phenyl, R.sup.2 is hydrogen or lower alkyl, n is an integer of 2 to 10, is useful as an effective component of anti-inflammatory agent or antiallergic agent.

Derivative of piperazine having anti-allergic and anti-inflammatory

Growing community of inventors

Tokorozawa, Japan

Kazuo Ogawa