Kuraray Co., Ltd.

Nihon Iyakuhin Kogyo Co., Ltd.

Kazuo Kumamoto

Yoshiaki Omura

Yoichi Ninagawa

Masao Mizuno

Yuki Nogami

Muneo Kobayashi

Michitaka Ogawa

Hiromasa Nakamoto

Hiroko Murakami

A geranylgeranylacetamide compound having a piperazine ring represented by the following formula (I) ##STR1## wherein R represents a member selected from the class consisting of a hydrogen atom, C.sub.1 -C.sub.5 alkyl groups which are unsubstituted or mono-substituted by a halogen atom, C.sub.2 -C.sub.5 alkenyl groups and C.sub.7 -C.sub.8 aralkyl groups, R.sub.1 represents a C.sub.1 -C.sub.3 alkyl group, and n represents 0, 1 or 2, and a pharmaceutically acceptable acid addition salt thereof. The aforesaid compound can be prepared by reacting geranylgeranylacetic acid or its reactive derivative with a piperazine compound, and thereafter, if desired, transforming the free geranylgeranylacetamide compound thus obtained into its pharmaceutically acceptable acid addition salt. A pharmaceutical composition containing said compound exhibits antiulcerogenic activity, particularly excellent antipeptic ulcerogenic activity, and is useful as an agent for treating ulcers.

Geranylgeranylacetamide compounds having a piperazine ring, salts

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Toyama, Japan

Kazuo Kumamoto