The Green Cross Corporation

Kazuo Ikegaya

Haruhide Kawabe

Kiyoshi Tsutsui

Ken Okabayashi

Yukimitsu Nakagawa

Yutaka Ishida

Kohji Murakami

Hitoshi Minamino

Naofumi Hayasuke

Sadao Ueda

Kaoru Kobayashi

Hirofumi Arimura

Hideo Nishimaki

Tuyoshi Takahashi

Atsushi Masaki

Atusi Masaki

Shinobu Mochizuki

The process for producing the albumin preparation of the present invention comprises treating an aqueous albumin solution with an anion exchanger and a cation exchanger and subjecting the solution to heat treatment wherein a polyacrylamide type carrier having a cation exchange group is used as a cation exchanger. By using a polyacrylamide type carrier as a cation exchanger, the polymerization caused by the contaminating proteins can be suppressed, and a highly purified albumin preparation can be obtained.

Process for producing albumin preparation

A method for preparing foreign protein in yeast using an expression recombinant DNA comprising DNA encoding the serum albumin signal peptide adjacent to DNA encoding the foreign protein is disclosed.

Method of preparing foreign protein in yeast, recombinant DNA,

Novel signal peptides capable of functioning in yeasts have the amino acid sequence:

DNA's encoding signal peptides

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Osaka, Japan

Kazuo Ikegaya