Chugai Seiyaku Kabushiki Kaisha

Kazuo Igusa

Toshichika Ogasawara

Sadao Bessho

Heizi Ikushima

Takashi Mori

Minoru Shindo

Yasushi Murakami

Yoshimitsu Iida

Sakae Takaku

Takashi Matsuno

Shigeyuki Kataoka

Yoshiyuki Ohsugi

Kaoru Nemoto

Yasuhisa Takeda

Kouji Ishihara

Akira Okazaki

Akiko Ariga

Kohtaro Miwa

Hiroto Nakano

Shoichi Higo

Pharmaceutical composition containing sucralfate

A process for making a stable pharmaceutical preparation of prostaglandin E compounds and/or 15R forms thereof is diclosed. Prostagladin E compounds and 15R forms thereof are know to have useful pharmacological actions even if they are used in a vary small amounts. However, they are extremely unstable and, therefore, considerably difficult in application for routine clinical purposes. In order to remove this difficulty, prostagladin E compounds and 15R forms thereof are formulated into a stable preparation by filling a hard capsule with a solution or a suspension thereof.

Process for making a stable pharmaceutical preparation of prostagladin E

A preparation containing an active form of vitamin D.sub.3 which is stabilized by incorporation of an amino acid that is neither one containing a sulfur atom or an acid amino group in its structure, nor an acidic amino acid, nor a salt of a basic amino acid is disclosed. Examples of said amino acids that may be used as stabilizers of the active form of vitamin D.sub.3 include neutral amino acids such as alanine, valine, proline, phenylalanine, tryptophan, leucine, isoleucine, glycine and serine, and basic amino acids such as lysine, arginine and histidine.

Stabilized active forms of vitamin D.sub.3

A storage-stable sucralfate-containing preparation which maintains its ability, even after extended periods of time, to form a viscous, sticky, paste-like material in the presence of gastric secretions is disclosed as well as the method of making same.

Formulation of sucralfate

A stabilized oily preparation of a 1.alpha.-hydroxy-vitamin D for oral administration comprising a 1.alpha.-hydroxy-vitamin D and, as oily diluent, a triglyceride of saturated middle chain fatty acid which has been treated under certain conditions, and a method for manufacturing the same are disclosed.

Stabilized oily preparation of 1.alpha.-hydroxy-vitamin D and method for

A terephthalic acid monoamide derivative of the formula: ##STR1## (wherein R is a straight- or branched-chain lower alkyl group; R' and R' may be the same or different, and represent a hydrogen atom, or a straight- or branched-chain lower alkyl group) or pharmaceutically acceptable salts thereof are disclosed. A process for preparing such terephthalic acid monoamide derivative or its salts, as well as an anti-allergic agent containing such derivative or its salts as an effective ingredient are also disclosed.

Terephthalic acid monoamide derivatives, process for preparing the same,

A soft gelatin capsule preparation of a 1.alpha.-hydroxy-vitamin D which contains sorbic acid or its salt and a process for preparing the preparation are disclosed. Sorbic acid or its salt which is incorporated in a soft gelatin capsule and/or an oily diluent acts as a preservative for gelatin and as a stabilizer for the vitamin D.

Stabilized soft gelatin capsule composition of 1 .alpha.-hydroxy-vitamin

Growing community of inventors

Tokyo, Japan

Kazuo Igusa