Toray Industries, Inc.

Kazuo Hosoi

Hitoshi Ozawa

Jun Utsumi

Norio Kawabe

Masaji Ohno

Masanobu Naruto

Emiko Sano

Makoto Kihara

Shingou Sakurai

Shigeru Ichikura

Keizo Hanada

The present invention relates to compositions containing human interleukin-6 with sugar chains, a process for preparing human interleukin-6 by culturing cells in a medium containing ascorbic acid or any of its derivatives, and a process for purifying a crude raw human interleukin-6 solution by chromatography using a carrier with heparin bound. The present invention has allowed the production of high quality human interleukin-6 compositions with sugar chains, and their application to medicines. Furthermore, it has established a process for massproducing human interleukin-6.

Interlekin-6 compositions, and a production process thereof

A method for the purification of human interferon by the successive treatments of a crude interferon solution with an immobilized carrier which is coupled with a blue dye and a chelating carrier which contains a chelating residue chelated with at least one metal ion selected from the group consisting of Co.sup.2+, Ni.sup.2+ and Zn.sup.2+.

Purification method of human interferon

A method for the purification of human fibroblast interferon by the successive treatments of a crude interferon solution with a strongly acidic ion exchanger and a chelating carrier which contains a chelating residue chelated with at least one metal ion selected from the group consisting of Co.sup.++, Ni.sup.++, Zn.sup.++, and Cu.sup.++.

Purification method of human fibroblast interferon

High purity cis-epoxysuccinic acid and salts thereof are economically and systematically prepared by contacting an aqueous solution, obtained by reacting a maleic acid salt and hydrogen peroxide in the presence of a tungstate or molybdate catalyst under a specified condition, with a strongly basic Type II anion exchange resin.

Process for preparing CIS-epoxysuccinic acid salts of high purity

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Kamakura, Japan

Kazuo Hosoi