Johnson and Johnson Vision Care, Inc.

Nektar Therapeutics

University of Colorado

Nektar Therapeutics Al, Corporation

Kazunori Emoto

Xuan Zhao

Zhongxu Ren

Kazunori Kataoka

Yukio Nagasaki

Michihiro Iijima

Wounjhang Park

Thomas Flaig

Xiaoping Yang

Lih-Jen Shih Su

Xuan S Zhao

The invention relates to a multifunctional nanomaterial comprising a nanorod comprising 1) a noble metal, wherein the nanorod exhibits surface plasmon resonance absorption in the near-infrared spectrum; 2) an up-conversion phosphor that absorbs infrared light and emits visible luminescence; and optionally 3) a biomolecule targeting moiety. The invention further relates to methods of detecting and treating cancer using the multifunctional nanomaterials of the invention.

Multifunctional nanomaterials for the treatment of cancer

The invention provides a multi-arm block copolymer for use in delivering a variety of bioactive agents. The copolymer of the invention contains a central core from which extend multiple (3 or more) copolymer arms. Each copolymer arm possesses an inner polypeptide segment and an outer hydrophilic polymer segment. Thus, the overall structure of the copolymer comprises an inner core region that includes the central core and the inner polypeptide segment, while the outer core region is hydrophilic in nature. The multi-arm copolymer of the invention is particularly useful for delivery of biologically active agents that can be entrapped within the inner core region.

Multi-arm polypeptide-poly(ethylene glycol) block copolymers as drug delivery vehicles

The present invention is directed to a coated biomedical device said micelle having a hydrophilic outer shell and a hydrophobic inner core, or a hydrophobic outer shell and a hydrophilic inner core said micelle comprised of a block copolymer having a HLB value ranging from about 1 to about 40. The medical device may have one coating thereon or multiple coatings. The present invention is also directed to the use of the micelle as a drug carrier.

Polymer micelle as monolayer or layer-laminated surface

Multi-arm polypeptide-poly (ethylene glycol) block copolymers as drug delivery vehicles

Growing community of inventors

Broomfield, CO, United States of America

Kazunori Emoto