Sagami Chemical Research Center

Kabushiki Kaisya Advance Kaihatsu Kenkyujo

Harima Chemicals, Incorporated

Kabushiki Kaisha Advance Kaihatsu Kenkyujo

Sagami Chemical Research

Nippon Shoji Kaish Ltd.

Kazunaga Yazawa

Kiyosi Kondo

Yasuo Kawai

Seishi Kato

Hirotaka Shimohashi

Akiko Yamada

Nobuo Suegara

Hisao Kondo

Masahiro Hayashi

Yorishige Matsuba

Yoshihisa Misawa

Naganori Numao

Yasuji Soda

Noriko Okazaki

Yasuharu Ijuin

Naoto Matsuyama

Koji Mizuno

Kazuo Watanabe

Tetsuya Tsutsumi

Ikuo Ikeda

Mitihiro Sugano

Hirofumi Taki

Tomohito Hamasaki

Keiko Araki

Mayumi Shikano

Tetsuya Kosaka

Hiroharu Nishigaki

Masashi Isozaki

Daisuke Sugimori

An aniline derivative of the formula (1) ##STR1## wherein R.sup.1 is an eicosapentaenoyl or docosahexaenoyl; R.sup.2 and R.sup.3 are each independently an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; R.sup.4 is a hydrogen atom, an alkyl or alkoxy having 1 to 6 carbon atoms, or a halogen atom; and A is a single bond, --C(.dbd.O)NH--(CH.sub.2).sub.n --NH-- wherein n is 2 or 3, or a bivalent group of the following formula ##STR2## wherein m and p are each independently 0 or 1. The aniline derivative of the present invention has high inhibitory activity against and high selectivity for ACAT derived from macrophage and is useful as an agent for the prophylaxis and treatment of arteriosclerosis.

Aniline derivative having polyunsaturated fatty acid residue and use

There is provided an advantageous process for production of EPA by a gene recombinant technique wherein genes coding for biosynthesis enzymes for eicosapentaenoic acid (EPA) useful as pharmaceuticals, agrochemicals, foods, feeds or the like is obtained from microorganisms. EPA is produced by obtaining genes coding for eicosapentaenoic acid (EPA) biosynthesis enzymes, constructing a plasmid by joining the genes to a vector, transforming E. coli with the plasmid, and culturing the transformed E. coli.

Gene coding for eicosapentaenoic acid synthesizing enzymes and process

Method for treating hepatitis

A process for the production of eicosapentaenoic acid comprising the steps of a) culturing a microorganism capable of producing lipid containing eicosapentaenoic acid belonging to a genus selected from the group of Pseudomonas, Alteromonas and Shewanella, to produce lipid containing eicosapentaenoic acid, and b) recovering the eicosapentaenoic acid from the cultured product; a process for production of a lipid containing eicosapentaenoic acid comprising the steps of a) culturing a microorganism capable of producing lipid containing eicosapentaenoic acid belonging to a genus selected from the group of Pseudomonas, Alteromonas and Shewanella, to produce lipid containing eicosapentaenoic acid, and b) recovering the lipid containing eicosapentaenoic acid; and microorganisms capable of producing eicosapentaenoic acid belonging to a genus selected from the group consisting of Pseudomonas, Alteromonas, and Shewanella.

Microbial process for production of eicosapentaenoic acid

[Object] A fatty acid-related polyunsaturated compound can be selectively purified using an industrially operable successive method under moderate conditions. [Content] A highly purified fatty acid-related polyunsaturated compound is obtained by a process comprising steps of forming a complex with silver on account of the high degree of unsaturation of the fatty acid-related polyunsaturated compound, isolating the complex from other fats on account of the hydrophilicity of the complex and then applying dissociating procedures to the complex to obtain the fatty acid-related polyunsaturated compound as a target substance on account of the hydrophobicity of the fatty acid-related polyunsaturated compound. As to the procedures for dissociation, addition of a dissociating agent and reduction of silver are disclosed. As to the dissociating agent, various compounds which produce insoluble composition with silver other then water are disclosed. Furthermore, an apparatus appropriately used to carry out this method is also disclosed.

Method of purifying polyunsaturated aliphatic compounds

Hypocholesterolemically and/or hypotriglyceridemically active RNA fractions having the following characteristics:

Hypocholesterolemically and/or hypotriglyceridemically active RNA

A hypocholesterolemically active protein capable of reducing the blood cholesterol in mammals having the following characteristics:

Hypocholesterolemically active protein derived from streptococcus

A bacterial cell product orally administered to lower serum cholesterol and/or triglyceride level in mammals obtained by cultivating a microorganism belonging to the genus Streptococcus and having a N-acetyl-.beta.-D-glucosaminidase activity in an adequate culture medium therefor, and collecting the cultivated microorganism from the resultant culture.

Hypocholesterolemically and/or hypotriglyceridemically active products

A hypotriglyceridemically active polysaccharide having the following characteristics:

Hypotriglyceridemically active polysaccharides

A bacterial cell product having hypocholesterolemic and/or hypotriglyceridemic activity in mammals obtained by cultivating a microorganism belonging to the genus Streptococcus and having a N-acetyl-.beta.-D-glucosaminidase activity in an adequate culture medium therefor, and collecting the cultivated microorganism from the resultant culture.

Growing community of inventors

Sagamihara, Japan

Kazunaga Yazawa