Aipore Inc.

Osaka University

Quantum Biosystems Inc.

Tokyo Institute of Technology

Tokyo Medical and Dental University

Kazumichi Yokota

Tomoji Kawai

Masateru Taniguchi

Makusu Tsutsui

Takashi Washio

Akihide Arima

Wataru Tonomura

Takeshi Yoshida

Masayoshi Tanaka

Yoshinobu Baba

Takao Yasui

Yuji Miyahara

Noritada Kaji

Mina Okochi

Akira Ishi

Yukichi Horiguchi

Akira Ishii

A number analyzing method, a number analyzing device, and a storage medium for number analysis are disclosed, which enable, with high accuracy, analysis of the number or number distribution of particulate or molecular analytes according to the kinds of the analytes. A computer control program is executed on the basis of a data group of particle-passage detection signals which are detected by a nanopore device in accordance with passage of subject particles through a through-hole. Also, a particle type distribution estimating program is executed, to estimate probability density on the basis of a data group based on feature values indicating feature of the waveforms of pulse signals which correspond to the passage of particles and which are obtained as the particle-passage detection signals. Thus, the number of particles can be derived for each particle type.

Number analyzing method, number analyzing device, and storage medium for number analysis

Provided is a channel device that is capable of increasing the concentration of fine particles in a liquid only by use of fluid-dynamic flows without relying on electrostatic interactions. A channel device () in accordance with an embodiment of the present invention includes: a main channel () configured to allow a liquid containing fine particles to flow therethrough; a chamber () that is provided at an end of the main channel () and that is configured to store target fine particles which have increased in concentration; and a side channel () that is connected to a side face of the main channel () and that is configured to allow unwanted liquid to drain therethrough, wherein at least one of a height and a width of the side channel () is smaller than a particle size of the fine particles.

Channel device and method for concentrating fine particles

It is an object to improve detection accuracy of an object as compared with prior arts. A flow passage () provided in a detection device () includes a substrate () and a covering member () provided at a position corresponding to the substrate (). A covering member opening (HL) of the covering member () is provided such that a substrate opening (HL) of the substrate () is not covered with the covering member (). The covering member () is arranged onto the substrate () such that a substrate capacitance and a covering member capacitance are connected in series. The covering member capacitance is lower than the substrate capacitance.

Flow passage

A device for biological material detection includes a substrate; a through-hole through which a biological material to be tested passes, the through-hole being formed in the substrate; a molecule that interacts with the biological material to be tested passing through, the molecule being formed in the through-hole; a first chamber member that forms, with at least the surface including the through-hole on one surface side of the substrate, a first chamber to be filled with electrolyte; and a second chamber member that forms, with at least the surface including the through-hole on the other surface side of the substrate, a second chamber to be filled with electrolyte. The biological material to be tested is identified by the waveform of the ion current (passage time, shape, etc.) when the biological material to be tested passes through the through-hole.

Device for biological material detection, detection apparatus for biological material detection, method for measuring ion current, and method for identifying biological material

The present invention provides technology that uses current measurements to identify nucleotides and determine a nucleotide sequence in polynucleotides. The present invention calculates a modal value of a tunnel current that arises when a nucleotide or polynucleotide for analysis passes through between electrodes, and then employs the calculated modal value. The present invention accordingly enables direct rapid implementation to identify nucleotides and to determine a nucleotide sequence in a polynucleotide without marking.

Method and device for identifying nucleotide, and method and device for determining nucleotide sequence of polynucleotide

Growing community of inventors

Osaka, Japan

Kazumichi Yokota