Senju Pharmaceutical Co., Ltd.

A. H. Robins Company, Incorporated

Kazumichi Ushio

Hisayuki Nakayama

Takahiro Ogawa

Katsuhiro Inada

Kenichi Yoshida

Akira Ohtori

Yoshifumi Ikejiri

Yoshikazu Kuribayashi

Yoshiki Makimoto

Ogata Kazumi

Takaichi Kinoshita

A composition for eye drops comprising as a main effective component 3,4-dihydro-2,8-diisopropyl-3-thioxo-2H-1,4-benzoxadine-4-acetic acid or a pharmaceutically acceptable salt thereof and cyclodextrin is disclosed.

Composition for eye drops

A method for inhibiting or preventing emergence and growth of algae, comprising use of a germanium compound and a herbicide, and an antialgal composition comprising a germanium compound and a herbicide. The method of the present invention inhibits and prevents emergence and growth of algae, and can be used safely with little influence on aquatic animals. The method is advantageously used for a fish tank in which fish for appreciation is kept, so as to keep good appearance of the tank and to reduce burden of cleaning the tank by preventing emergence and growth of attached algae. Particularly, the composition for artificial seawater of the present invention shows no toxicity to marine animals to be raised in the artificial seawater prepared using the composition of the invention, and can inhibit and prevent emergence of algae. Therefore, the composition of the invention can be beneficially used for raising, culture, study, and the like of marine animals. Moreover, the composition of the present invention which is coated on a fish net, a hull, or the like can result in inhibition and prevention of emergence and growth of algae in the environment where influence on fish, etc. is very little.

Method for preventing emergence of algae and antialgal composition

Method for preparation of an aqueous suspension

An improved composition for preparing artificial sea-water comprises an electrolyte mixture which, upon being dissolved in a proper amount of water, forms an aqueous solution which simulates natural sea-water in composition except that it contains one or more boron compounds within a concentration range from 0.002 to 0.05 w/v % calculated as boron. The pH stability of an artificial sea-water is improved by adding one or more boron compounds thereto.

Artificial sea-water

Presented is a stable aqueous preparation for ophthalmic topical administration containing vitamin A or a vitamin A derivative having vitamin A activities to be used for the treatment of dry eye syndrome characterized in that it contains a buffering component selected from the group consisting of phosphoric acid, boric acid, citric acid, glutamic acid, .epsilon.-aminocaproic acid and the alkali metal salts thereof, a non-ionic surfactant and a chelating agent, that its acidity is adjusted in the range of pH 5 to pH 8, and that it is filled in a tight container made of polypropylene or polyethylene terephthalate.

Stable aqueous preparation

The object of the invention is to provide a method of cleaning a hard contact lens which is easy to use, excellent in the cleaning effect and then does not affect the lens material disadvantageously. The method of cleaning a hard contact lens is characterized in that the hard contact lens adhered with soil is immersed in a mixture of an aqueous solution of a permanganate salt and an aqueous solution of a mild reducing substance.

Method of cleaning hard contact lenses

This invention relates to a locally administrable therapeutic composition for inflammatory disease which is characterized by comprising benzoylphenylacetic acid of the formula ##STR1## (wherein R is a hydrogen or halogen atom), or a salt thereof, or the hydrate of said acid or salt, as active ingredient. An ophthalmic composition according to the invention can treat effectively inflammatory eye disease by topical application, is not an irritant to the eye, and has a superior effect to conventional drugs of the same or similar type. The aqueous composition prepared in accordance with this invention has excellent stability and can be used advantageously as a nasal or otic composition as well as an ophthalmic one in the treatment of inflammatory otic or nasal disease.

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Nishinomiya, Japan

Kazumichi Ushio