Canon Kabushiki Kaisha

Canon Medical Systems Corporation

Kazumichi Nakahama

Shinnosuke Koji

Takayuki Teshima

Yukio Hanyu

Shuntaro Watanabe

Takayuki Hiratani

Kenji Aoki

Atsushi Tani

Akira Kuriyama

Tetsuya Kinumatsu

Yusuke Kosaki

Noritaka Toyoizumi

Takashige Kasuya

Sakae Suda

Ryuji Higashi

Toshifumi Mori

Takeshi Imamura

Shoji Koike

Katsuhisa Yamazaki

Takaaki Kaya

Takashi Ikeda

Takeshi Sekiguchi

Shuhei Moribe

Keiichiro Tsubaki

Hiroki Akiyama

Atsuhiko Ohmori

Tatsuya Saeki

Hironori Yamamoto

Masato Minami

Fumio Yamauchi

Takeo Suga

Minako Nakasu

Kengo Kanazaki

Masatoshi Watanabe

Taku Shimoda

Miki Ogawa

Rie Ueno

Yutaka Tani

Ryo Natori

Tetsunori Ojima

Masao Suzuki

Shohei Fukuya

Toshihiko Hiaki

Kiwamu Sue

Hayato Hattori

Mamoru Sakashita

The present disclosure provides a particle showing a small non-specific adsorption, having a reactive functional group for chemically bonding a ligand thereto, and being suitable for an agglutination method; a particle for the agglutination method having a ligand chemically bonded to the particle; a reagent, a kit and a method for detecting a target substance, each for in vitro diagnosis, each of which contains the particle. The particle includes a polymer having a unit having a linker A in a side chain, wherein when both terminals of the linker A are represented by X1 and X2, the linker A has a reactive functional group for chemically bonding a ligand thereto in one of X1 and X2; one of X1 and X2 includes an ester structure; and a sum of bonds between atoms linearly connecting X1 and X2 is 18 to 24 and the X1 and X2 contain CHor CH.

Particle, particle for agglutination method, and reagent, kit and detection method containing the same

Provided is an external additive having a resin particle containing a crystalline resin, and an inorganic fine particle containing a metal atom, the inorganic fine particle being embedded in the resin particle, wherein part of the inorganic fine particle being exposed on a surface of the resin particle, the maximum endothermic peak temperature of the external additive during a first temperature rise is from 50.0&#xb0; C. to 120&#xb0; C., the shape factor SF-2 of the external additive is from 110 to 150, and the external additive satisfies following formulae (1) and (2) below, in which Za (mass %) is the percentage content of a metal atom contained in the inorganic fine particle on the surface of the external additive in X-ray photoelectron spectroscopy, and Zb (mass %) is the percentage content of the metal atom in thermogravimetric analysis of the external additive,&#x2265;15&#x2003;&#x2003;(1), and&#x2265;0.7&#x2003;&#x2003;(2)

External additive, method for manufacturing external additive, and toner

An external toner additive having a resin fine particle containing a crystalline resin and an inorganic fine particle embedded in the resin fine particle, wherein part of the inorganic fine particle is exposed on the surface of the resin fine particle, and in differential scanning calorimetry of the external toner additive, the maximum endothermic peak temperature T1 (&#xb0; C.) during a first temperature increase and the maximum exothermic peak temperature T2 (&#xb0; C.) during a first temperature decrease satisfy the formulae (1) to (3) below, with measurement performed between &#x2212;40&#xb0; C. and 150&#xb0; C. at a rate of increase of 10&#xb0; C./min during the first temperature increase and between 150&#xb0; C. and &#x2212;40&#xb0; C. at a rate of decrease in temperature of 10&#xb0; C./min during the first temperature decrease:1-2&#x2264;40.0&#x2003;&#x2003;(1)50.0&#x2264;1&#x2264;120.0&#x2003;&#x2003;(2)10.0&#x2264;2&#x2264;80.0&#x2003;&#x2003;(3).

External toner additive, method for producing external toner additive, and toner

A method of producing a toner including the steps of: mixing resin fine particles, an organic solvent, and a resin R with a dispersion medium containing carbon dioxide, to prepare a dispersion of resin R-containing droplets; and removing the organic solvent by flowing carbon dioxide, wherein the resin fine particles contain one or more resins that have a partial structure A, B, and C, and are soluble in chloroform; the SP value of the partial structure A, the resin R, and the partial structure B satisfy particular relationships; a resin A constituted of the partial structure A and a resin B constituted of the partial structure B are soluble in the organic solvent; and a resin C constituted of the partial structure C is insoluble in the organic solvent.

Resin fine particles, method of producing resin fine particles, method of producing resin particles, and method of producing toner

A method for producing a toner particle include: (a) mixing a binder resin A, resin fine particles containing a resin B, a resin C, an organic solvent, and carbon dioxide, thereby forming a droplet of a resin solution containing the binder resin A, covered with the resin fine particles; (b) applying a pressure by introducing carbon dioxide, thereby precipitating the resin C at the surface of the droplet; and (c) passing carbon dioxide so as to remove the organic solvent from the droplet with the carbon dioxide. The resin C has an organic polysiloxane structure and a weight average molecular weight of 50,000 to 500,000. The ratio of the weight average molecular weight to the number average molecular weight of the resin C is not more than 5.0. The proportion of the resin C to the rein fine particles is 5.0% by mass to 50.0% by mass.

Methods for producing toner particle and producing resin particle

A toner includes toner particles which contain a binder resin, a colorant, a wax, and a resin A having an organic polysiloxane structure; the amount of Si atoms of the toner particles is 4.5 to 10.0; in an analysis of a cross-section of each toner particle, in a surface layer region R from the periphery of the cross-section of the toner particle to the inside at a distance of 10.0% of the particle diameter in the cross-section of the toner particle, the content of Si atoms derived from the organic polysiloxane structure is 90.0% or more with respect to the total amount of Si atoms contained in the toner particle; and in a line analysis along a straight line between the periphery of the surface layer region R and a gravity center of the cross-section, an intensity count of Si atoms in the toner particle satisfies formula Si&#x3e;Si&#x3e;Si&#x3e;Si&#x2265;0.

Toner and method for manufacturing the same

Provided is a toner, comprising a toner particle having a core-shell structure composed of a core particle and a shell phase on a surface of the core particle, the core particle containing a resin X and a colorant, the shell phase being derived from a resin fine particle containing a resin Y, in which a relationship among a SP value of the resin X, a SP value of the resin Y, and a SP value of an organic solvent falls within a specific range, and a relationship between a number-average particle diameter of the resin fine particle when the resin fine particle is dispersed in water and a number-average particle diameter of the resin fine particle when the resin fine particle is dispersed in the organic solvent falls within a specific range.

Resin particle and method of producing the resin particle, and toner and method of producing the toner

Provided is a method of producing a toner including the steps of: mixing a resin solution comprising a resin R, a colorant, and an organic solvent, a resin fine particle comprising a resin S containing an element &#x3b1;, and carbon dioxide to form a droplet having a surface covered with the resin fine particle; introducing carbon dioxide in a liquid state and pressurizing to extract the organic solvent in the droplet; and removing the extracted organic solvent together with the carbon dioxide to provide a toner particle. In the method of producing a toner, when the resin fine particle is treated with the carbon dioxide in a liquid state, a change in amount of the element &#x3b1; on the surface of the resin fine particle after the treatment as compared to the amount before the treatment falls within a specific range.

Method of producing toner

A method for producing a resin composition, comprising the step of: subjecting a radical copolymerization of a first radical polymerizable monomer which is free from any crystalline molecular chain and a second radical polymerizable monomer having a crystalline molecular chain, in the presence of a radical polymerization initiator, (wherein Rdenotes a hydrogen atom or a methyl group, and Rdenotes an alkyl group having at least 17 carbon atoms) the first radical polymerizable monomer has a particular reactivity ratio.

Method for producing resin composition and resin composition

A method for producing polymer particles includes a suspension step of suspending a first liquid mixture containing an oily olefin monomer and a radical polymerization initiator in a second liquid mixture containing water, an iodide ion, and an iodine molecule, to prepare a suspension in which an oil droplet containing the oily olefin monomer and the radical polymerization initiator is dispersed in the water containing the iodide ion and the iodine molecule, a synthesis step of synthesizing an iodine compound by allowing a radical generated by cleavage of the radical polymerization initiator to react with the iodine molecule in the oil droplet, and a polymerization step of polymerizing the oily olefin monomer in the oil droplet.

Method for producing polymer particles

A method for producing polymer particles includes a suspension step of suspending a first liquid mixture containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule in a second liquid mixture containing water and an iodide ion to prepare a suspension containing an oil droplet having the first liquid mixture; a synthesis step of synthesizing an iodine compound by allowing a radical generated by cleavage of the radical polymerization initiator to react with the iodine molecule in the oil droplet; and a polymerization step of polymerizing the oily olefin monomer in the oil droplet.

A method for producing polymer particles includes a preparation step for preparing a first oily liquid containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule; a synthesis step for obtaining a second oily liquid containing at least an iodine compound produced by a reaction between a radical generated by cleavage of the radical polymerization initiator and the iodine molecule in the first oily liquid; a suspension step for obtaining an oil droplet of the second oily liquid by suspending the second oily liquid in an aqueous solution containing an oxidizing agent, an acid, and a dispersant; and a polymerization step for polymerizing the oily olefin monomer in the oil droplet.

A method for producing polymer particles includes a preparation step for preparing a first oily liquid containing an oily olefin monomer, a radical polymerization initiator, and an iodine molecule, a synthesis step for obtaining a second oily liquid containing at least an iodine compound produced by a reaction between a radical generated by cleavage of the radical polymerization initiator and the iodine molecule in the first oily liquid, a suspension step for obtaining an oil droplet of the second oily liquid by suspending the second oily liquid in water, and a polymerization step for polymerizing the oily olefin monomer in the oil droplet.

Provided is a detection method for a target substance capable of enhancing detection sensitivity and quantitative property of a magnetic biosensor, while keeping monodispersity and dispersion stability of magnetic markers, including the steps of: reacting the target substance in a sample solution with a first target substance trapping member immobilized on a sensing element and with a second target substance trapping member immobilized on a gel particle to hold the gel particle on the sensing element; adjusting a magnetic marker precursor including the gel particle and a magnetic material precursor existing in the gel particle by bringing the magnetic material precursor into contact with the gel particle; synthesizing a magnetic material from the magnetic material precursor held on the gel particle, thereby adjusting the magnetic markers; and detecting the magnetic markers with the sensing element.

Method of detecting target substance and target-substance detection kit

Provided is a microwave reactor including a reaction container for receiving a reaction solution, a microwave radiator for irradiating the reaction solution received in the reaction container with microwaves, and a cooler for cooling the reaction solution received in the reaction container, wherein a heat-generating medium generating heat by absorbing the microwaves is arranged on a surface of the cooler or in the vicinity of the surface at a position receiving the microwaves from the microwave radiator through the reaction solution.

Microwave reactor and method of producing polymer compound using the same

Growing community of inventors

Tokyo, Japan

Kazumichi Nakahama