Chugai Seiyaku Kabushiki Kaisha

Kazumi Morikawa

Masahiro Nishimoto

Yoshitake Kanbe

MyungHwa Kim

JaeChon Jo

Jaeyoung Choi

HeeAn Kwon

Jong Min Kim

Yoshikazu Nishimura

JongMin Kim

Jae Chon Jo

Hyun Suk Lim

HyunSuk Lim

PilSu Ho

Myung Hwa Kim

Ju Su Kim

Takashi Emura

Akira Kawase

Masamitsu Honda

Masayuki Ohmori

Kazuki Shimizu

JuSu Kim

KooHyeon Ahn

SungOh Ahn

YoungJun Na

HongIl Heo

HongKi Kim

SungDae Park

Kohichi Endoh

The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): 

Vitamin D derivatives

The present invention provides a compound consisting of a moiety and a group chemically bonded to said moiety, wherein said moiety contains a compound having low activity following oral administration or its parent scaffold and said group has the following general formula (1): in which

Compounds with hydroxycarbonyl-halogenoalkyl side chains

The present invention relates to a novel benzopyran or thiobenzopyran derivative represented by formula (1): pharmaceutically acceptable salt or stereoisomer thereof, in which X, R, R, R, Rand A are defined as described in the specification, and to a process for preparation thereof and a pharmaceutical composition having anti-estrogenic activity which contains the compound (1) as an active component.

Benzopyran or thiobenzopyran derivatives

Compounds with hydroxycarbonyl-halogenoalkyl side chain

Optically active chroman and thiochroman derivatives

The present invention relates to 3-methyl-chromane or thiochromane derivatives, pharmaceutically acceptable salts, stereoisomers or hydrates thereof, and an anti-estrogenic pharmaceutical composition which comprises the above compound as an active component.

3-methyl -chromane or thiochromane derivatives

3-ethyl-, 3-propyl- or 3-butyl-chroman and thiochroman derivatives

3-methyl-chroman and -thiochroman derivatives

Novel platinum complexes represented by the formula: ##STR1## wherein A is alkylene having carbon atoms of from 1 to 3; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are the same or different and are hydrogen or alkyl having carbon atoms of from 1 to 4; X and Y are independently a halogen atom, or combined together to form ##STR2## and l, m and n are independently 0 or 1, and a process for preparing the same are disclosed. These platinum complexes have high antitumor activity and low toxicity, and are easily soluble in water. Therefore, they are very useful as an antitumor agent.

N-heterocyclic platinum complexes

Growing community of inventors

Shizuoka, Japan

Kazumi Morikawa