Nippon Gohsei Kagaku Kogyo Kabushiki Kaisha

The Nippon Synthetic Chemical Industry Co., Ltd.

Yoshiharu Miura

Kazumasa Hirata

Akio Katsuura

Takeo Kawabata

Toshio Yamamoto

Akira Taisha

Takehiko Kakimoto

Naritoshi Kawata

Azusa Yonezawa

Keisuke Tsuzuki

Shigenori Wakabayashi

A 5-(2-substituted-4-nitrophenyl)-oxazole is prepared by decarboxylating a 5-(2-substituted-4-nitrophenyl)-4-oxazolecarboxylic acid in an aprotic amide solvent containing a protic compound. A 5-(2-substituted-4-nitrophenyl)-oxazolecarboxylic acid and a 5-(2-substituted-4-nitrophenyl)-carboalkoxyoxazole, which are novel compounds, are provided.

Process of preparing 5-(2-substituted-4-nitrophenyl)-oxazole, novel oxazole compound, and process of preparing the same

Disclosed is a process for producing an N-alkylimidazole which comprises reacting an imidazole with an N-alkylating agent in an organic solvent in the presence of alkali particles having a specific surface area of 0.6 M.sup.2 /g or larger.

Process for producing N-alkylimidazole

In producing formylimidazoles by catalytically oxidizing the corresponding 4- or 5-hydroxymethylimidazoles, the catalytic oxidation is carried out in the presence of a noble metal catalyst while oxygen or air is blown into the reaction system. In this case, it is particularly desirable that the catalytic oxidation in the presence of a noble metal catalyst be carried out in a solvent comprising an aqueous alkali or in a mixed solvent composed of an aqueous alkali and an organic solvent immiscible with water.

Method of producing formylimidazoles

A method of preparing an organ culture from branched tissue of a Catharanthus roseus seedling is disclosed. The indole alkaloids vincristine and vinblastine can be recovered from the organ culture tissue via extraction.

Use of an organ culture of Catharanthus roseus to produce vincristine

A process for preparing an aminoacetaldehyde dialkyl acetal which comprises reacting a halogenoacetaldehyde dialkyl acetal with ammonia or an alkylamine in an aqueous medium in the simultaneous presence of an alkali metal hydroxide or of an alkaline earth metal hydroxide, and distilling the resulting reaction mixture.

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Osaka, Japan

Kazumasa Hirata