Toyo Jozo Kabushiki Kaisha

Kumiai Chemical Industry Co., Ltd.

Kumiai Kagaku Kogyo Kabushiki Kaisha

Kazuko Yamamoto

Isao Chiyomaru

Noriyasu Takayanagi

Kazuo Nishio

Hiroshi Ohno

Katsuo Anma

Compounds of the formula wherein R is ##STR1## in which R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, lower alkyl, lower alkoxy and naphthyl, provided that when R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 are hydrogen, chlorine, bromine or lower alkoxy, or a pharmaceutically acceptable salt thereof, have anti-carrageenin edema activity, and are useful as anti-inflammatory agents and immuno modulators. They are produced by reacting an amide of the formula ##STR2## wherein R has the same meanings hereinabove, with N,N'-ethylene thiourea.

2,3-di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts,

Compounds of the formula ##STR1## wherein R is ##STR2## in which R.sub.1, R.sub.2 and R.sub.3 are the same or different and are selected from the group consisting of hydrogen, chlorine, bromine, lower alkyl, lower alkoxy and naphthyl, provided that when R.sub.1 is lower alkyl, R.sub.2 and R.sub.3 are hydrogen, chlorine, bromine or lower alkoxy, or a pharmaceutically acceptable salt thereof, have anti-carrageenin edema activity, and are useful as anti-inflammatory agents and immuno modulators. They are produced by reacting an amide of the formula ##STR3## wherein R has the same meanings hereinabove, with N,N'-ethylene thiourea.

2,-3-Di-substituted-5,6-dihydroimidazo [2,1-b] thiazole, its salts,

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Kazuko Yamamoto