Kyorin Pharmaceutical Co., Ltd.

Nisshin Pharma Inc.

Nisshin Seifun Group Inc.

Nisshin Foods Inc.

Kazuko Kojima

Masashi Suzuki

Koji Kawamura

Hitoshi Inoue

Takuya Kishimoto

Rie Shibayama

Kouichirou Hagihara

Tatsunori Nishide

Ryuuta Fukutomi

Kentaro Irie

Takashi Sesai

Takashi Ito

There are provided novel 4(2-furoyl)aminopiperidines represented by the general formula (I), their synthetic intermediates, processes for their preparation and medicaments containing them. In the above formula, X is OH or N, and Y is a group of the following general formula (II), formula (II-a) or formula (III):  The 4-(2-furoyl)aminopiperidine derivatives according to this invention possess opioid &#x3bc; antagonistic activity and are useful for the treatment or prevention of side effects which are caused by &#x3bc; receptors agonist and which are selected from constipation, nausea/emesis or itch, or for the treatment or prevention of idiopathic constipation, postoperative ileus, paralytic ileus, irritable bowel syndrome or chronic pruritus.

4-(2-furoyl) aminopiperidines, intermediates in synthesizing the same, process for producing the same and medicinal use of the same

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Iruma-gun, Japan

Kazuko Kojima