Meiji Seika Kaisha, Ltd.

Other

Koichi Shudo

Kazuko Kobayashi

Katsuyoshi Iwamatsu

Yasuo Sato

Fukio Konno

Megumi Yamada

Takashi Ida

Kunio Atsumi

Takashi Ando

Takahiro Imai

Toshiro Sasaki

Kiyoaki Katano

Yuko Kano

Kazuhiro Aihara

Tomoaki Miura

Kenichi Fushihara

Shokichi Ohuchi

Hisashi Suzuki

Eijirou Umemura

Eiji Matsuura

Hiromasa Takizawa

Yumiko Toyooka

Kazumi Ota

Kazumasa Aizawa

The cholesterol derivative, represented by the following formula (1): wherein R represents a C3&#x2013;C23 saturated or unsaturated aliphatic hydrocarbon residue having an optional substituent, and, to the cholesterol backbone, &#x2014;OH, &#x2014;CHO, &#x2014;COOH, &#x2014;OOH, or an epoxy group may be added, specifically binds to &#x3b2;-glycoprotein. By use of the derivative, &#x3b2;-glycoprotein or a similar substance can be assayed in a very practical manner. Through the assay, a disease can be detected in a very practical manner.

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This invention provides a serotonin 5-HTreceptor partial activator which has a serotonin 5-HTreceptor activating action, in addition to its serotonin 5-HTreceptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HTreceptor antagonism and serotonin 5-HTreceptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HTreceptor partial activators. In the above formula, Rto Rmay be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of Rand Rmay be linked together to form a ring structure, namely benzene ring; Rrepresents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

Serotonin 5-HT3 receptor partial activator

Nitrogen-containing heterocyclic compounds having antiplatelet aggregation effect and medicinal use thereof

The carbapenem derivatives represented by the following formula (I) is disclosed. These compounds have strong anti-bacterial activities against bacteria including methicillin resistant,, penicillin resistant,, Enterococci, influenza, and &bgr;-lactamase producing bacteria, and have high stabilities to DHP-1

Carbapenem derivatives

This invention provides a serotonin 5-HT,receptor partial activator which has a serotonin 5-HT,receptor activating action, in addition to its serotonin 5-HT,receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT,receptor antagonism and serotonin 5-HT,receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT,receptor partial activators.

Serotonin 5-HT3, receptor partial activator

A compound represented by the following formula (I) is disclosed. This compound has potent antimicrobial activity against a wide spectrum of bacteria from Gram-positive bacteria to Grame-negative bacteria including &bgr;-lactamase producing bacteria. In particular, it has higher antimicrobial activity against methicilline-resistant Staphylococcus aureus (MRSA), penicillin-resistant Streptococcus pneumoniae (PRSP), and imipenem-resistant Pseudomonas aeruginosa than the existing onium salt type cephem derivatives and hence is very useful as a therapeutic agent for infectious diseases derived from various pathogenic bacteria.

Cephem derivatives

This invention provides a serotonin 5-HT.sub.3 receptor partial activator which has a serotonin 5-HT.sub.3 receptor activating action, in addition to its serotonin 5-HT.sub.3 receptor antagonism, and does not cause constipation as a side effect. Particularly, based on the finding that newly synthesized benzoxazole derivatives typified by the compounds of the following formula (2) have strong serotonin 5-HT.sub.3 receptor antagonism and serotonin 5-HT.sub.3 receptor activating action, this invention provides these benzoxazole derivatives as serotonin 5-HT.sub.3 receptor partial activators. ##STR1## In the above formula, R.sub.1 to R.sub.4 may be the same or different from one another and each represents a hydrogen atom, a halogen atom, a substituted or unsubstituted lower alkyl group, a substituted or unsubstituted lower alkenyl group or a substituted or unsubstituted amino group, or two groups of R.sub.1 and R.sub.2 may be linked together to form a ring structure, namely benzene ring; R.sub.5 represents a hydrogen atom, a substituted or unsubstituted lower alkyl group or a substituted or unsubstituted lower alkenyl group; and m is an integer of 1 to 4.

Serotonin 5-HT.sub.3 receptor partial activator

Growing community of inventors

Kanagawa, Japan

Kazuko Kobayashi