The Biomembrane Institute

Seikagaku Corporation

Glyconex, Inc.

Kazuko Handa

Sen-itiroh Hakomori

Yasuyuki Igarashi

Mark R Stroud

Mary Ellen Salyan

Sen-Itiroh Hakomori

Jerry Ting

Hirofumi Okoshi

Shu-Yen Chang

Liahng-Yirn Liu

Tong-Hsuan Chang

Mei-Chun Yang

Mahammad N Ahmad

Mohammad N Ahmad

Ying-Jin Chen

Jaw-Yuan Wen

Tsai-Hsia Hong

Naoya Kojima

Satoshi Kimura

Ying-Zin Chen

Human antibodies and antigen-binding portions of those antibodies that specifically bind extended Type I chain glycosphingolipids are provided.

Anti-extended type I glycosphingolipid antibody, derivatives thereof and use

An unbranched polylactosamine comprising at least 6 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except for solely at the penultimate N-acetylglucosamine residue.

Carbohydrate ligands (myelorollin) that cause E-selectin dependent cell

The invention relates to antibodies that specifically bind a myelorollin comprising an unbranched polylactosamine comprising at least 10 monosaccharides and having terminal .alpha.2.fwdarw.3 sialylation and internal .alpha.1.fwdarw.3 fucosylation at various N-acetylglucosamine residues except the penultimate N-acetylglucosamine residue. The invention also relates to a method of using such antibodies to inhibit E-selectin-dependent rolling of a cell on another cell, wherein one of the cells expresses a myelorollin that binds the antibodies.

Antibodies that bind novel carbohydrate ligands (myelorollins) that

Effect of N,N,N-trimethylsphingosine on protein kinase-C activity;

O-glycosylation and O-glycosylation extension inhibitors influence selectin-dependent interactions between cells and between cells and platelets.

Method for inhibiting selectin-dependent adhesion of leukocytes and

The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory an anti-metastatic activity over related compounds.

Effect of N,N,N-trimethylsphingosine on protein kinase-C activity,

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Bellevue, WA, United States of America

Kazuko Handa