Shin-etsu Chemical Co., Ltd.

Ajinomoto Co., Ltd.

Kazukiyo Onodera

Shinichi Ito

Hiroshiro Shibai

Tatsuhiko Hongu

Satoshi Takano

Hajimu Morioka

Seiko Funabashi

Gilberto M Guterres

Ranko Obata

A method of separating a heavy metal ion from an aqueous solution containing the heavy metal ion, comprising the step of bringing a chitosan derived from a chitosan-producing microorganism into contact with said aqueous solution. The chitosan used, which can be produced by a simple process, has good heavy metal ion adsorptivity; this method can effectively separate heavy metal ion from a solution containing it.

Method of separating a heavy metal ion

An anti-AIDS virus agent comprising as an effective component a streptovaricin C derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 3 to 7 carbon atoms. The streptovaricin C derivative has good HIV-growth inhibiting activity, and this agent is useful for therapy of AIDS.

Method for treating AIDS using streptovaricin C compounds

An anti-HTLV-I agent comprising as an effective component a streptovaricin C derivative represented by the general formula (I): ##STR1## wherein R.sup.1 represents an alkyl group having 3 to 7 carbon atoms. The streptovaricin C derivative has good HTLV-I killing activity, and this agent is useful for therapy of diseases caused by HTLV-I.

Method for treating HTLV-I using streptovaricin C compounds

This invention relates to a human T or B cell line carrying at least one Ela human adenovirus 12-type gene or fragment thereof; said cell line being capable of spontaneously producing an immmunologically active substance. This invention also relates to a process for producing an immunologically active substance comprising culturing a human B- or T- cell line carrying at least one human Ela adenovirus 12-type gene or fragment thereof in a culture medium capable of supporting growth thereof for a period of time effective to attain a spontaneous production of the substance thereof.

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Tokyo, Japan

Kazukiyo Onodera