Chugai Seiyaku Kabushiki Kaisha

Kazuki Shimizu

Takashi Emura

Akira Kawase

Hitoshi Shimizu

Yoshiyuki Ono

Hirotaka Kashiwagi

Kazumi Morikawa

Tadakatsu Takahashi

Tsuyoshi Haneishi

Kazutomo Kinoshita

Masayuki Ohmori

The object of the present invention is to provide vitamin D derivatives that have excellent physiological activities as medicines, particularly as therapeutic agents for skin diseases such as psoriasis, and that have a reduced hypercalcemic effect. The present invention provides a vitamin D derivative of Formula (1): 

Vitamin D derivatives

The present invention provides a compound represented by the following general formula (I): or a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing such a compound, and the like. The compound or a pharmaceutically acceptable salt thereof, the pharmaceutical composition containing such a compound, or the like is useful as a medicine or the like for therapy of benign prostatic hyperplasia, cancer, osteoporosis, psoriasis, secondary hyperparathyroidism, chronic glomerulonephritis, lupus nephritis and/or diabetic nephropathy and the like.

Vitamin D-like compound

The object of the present invention is to provide a vitamin D derivative exhibiting excellent physiological activity as medicines, in particular as therapeutic agents for skin disease including psoriasis, and having decreased hypercalcemic activity. The present invention provides vitamin D derivatives represented by the general Formula (1): wherein 

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Shizuoka, Japan

Kazuki Shimizu