Tokyo Institute of Technology

Nof Corporation

Kazuki Osakama

Hiroki Yoshioka

Nobuhiro Nishiyama

Ken Hamura

Hiroyasu Takemoto

Makoto Matsui

Takahiro Nomoto

Mika Hamura

Takanori Inaba

Xiaohang Sun

A branched degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A branched degradable polyethylene glycol derivative represented by the following formula (1), containing, in a molecule, an oligopeptide that is degraded in the cells: wherein kand kare each independently 1-12, jand jare each independently 45-950, R is a hydrogen atom, a substituted or unsubstituted alkyl group having 1-12 carbon atoms, a substituted aryl group, an aralkyl group or a heteroalkyl group, Z is an oligopeptide that is degraded by enzyme in the cells, X is a functional group capable of reacting with a bio-related substance, and Land Lare each independently a single bond or a divalent spacer.

Asymmetrically branched degradable polyethylene glycol derivative

A multi-arm, degradable polyethylene glycol derivative with a high molecular weight that does not cause vacuolation of cells is provided. A degradable polyethylene glycol derivative represented by the following formula (1): wherein n1 and n2 are each independently 45-950, Wand Ware each independently an oligopeptide of 2-47 residues, a1 and a2 are each independently 1-8, Q is a hydrocarbon chain having 2-12 carbon atoms and optionally containing an oxygen atom and/or a nitrogen atom, Xand Xare each independently a functional group capable of reacting with a bio-related substance, and L, L, L, L, Land Lare each independently a divalent spacer.

Degradable multi-arm polyethylene glycol derivative

A bio-related substance bonded to a branched and degradable polyethylene glycol derivative that is degraded in the cells represented by the following formula (A): wherein each symbol is as defined in the present specification, is provided by the present invention.

Branched degradable polyethylene glycol binder

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Kawasaki, Japan

Kazuki Osakama