Maruishi Pharmaceutical Co., Ltd.

St. Marianna University School of Medicine

Kazuki Okamoto

Yutaka Nishihara

Masahiko Seto

Junji Okunishi

Manabu Soga

Tsuyoshi Miura

Fumihide Isohashi

A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection:

Disinfectant

A disinfectant comprising the following (a), (b), (c) and (d), but no other microbicidal disinfecting agents intended for microbicidal disinfection: (a) 40 to 90% (w/w) of ethanol, isopropyl alcohol or a mixture thereof; (b) 0.1 to 2% (w/w) of lactic acid; (c) 0.01 to 2% (w/w) of citric acid; and (d) 0.001 to 0.1% (w/w) of a zinc-containing compound which releases zinc ion in solution, relative to the whole disinfectant.

A microbicidal and antiseptic composition, which comprises the following (a), (b) and (c):

Microbicidal and antiseptic gel composition

It is intended to surely and effectively inhibit the transcriptional activity of NF&#x3ba;B and to obtain a more effective anti-inflammatory effect. Further, it is intended to obtain an equivalent effect even if the amount used of a steroid agent is reduced. An agent is characterized by containing MTI-II, especially a nucleic acid sequence of SEQ ID NO: 1, or a peptide of SEQ ID NO: 2. This MTI-II peptide is preferably a peptide containing at least an acidic amino acid domain (SEQ ID NO: 3). Further, a steroid agent such as triamcinolone acetonide is used concomitantly with MTI-II, especially the nucleic acid sequence of SEQ ID NO: 1 or the peptide of SEQ ID NO: 2.

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Osaka, Japan

Kazuki Okamoto