Eisai Company, Limited

Nec Corporation

Eisai R&d Management Co., Ltd.

Honda Motor Co., Ltd.

Nec Electronics Corporation

Kazuki Miyazaki

Masayuki Matsukura

Fumihiro Ozaki

Hiroki Ishihara

Junichi Kamata

Yasutaka Takase

Akihiko Tsuruoka

Nobuhisa Watanabe

Keiko Takahashi

Hideyuki Adachi

Tomohiro Matsushima

Takao Saeki

Yoshio Fukuda

Toshihiko Kaneko

Masanobu Zenke

Kazunobu Shigehara

Shigeru Souda

Shuhei Miyazawa

Tatsuo Watanabe

Kazutoshi Miyake

Yasuhiro Funahashi

Norio Karibe

Yuji Yamamoto

Yasuhiro Kabasawa

Hiroshi Obaishi

Itaru Tsukada

Keiji Ishibashi

Toru Haneda

Junji Matsui

Atsushi Kamada

Tadashi Nagakura

Yoshimitsu Naoe

Kohtarou Kodama

Kohtaro Kodama

Atsumi Yamaguchi

Katsuji Nakamura

Fusayo Mimura

Sachi Suzuki

Ken-ichi Nomoto

Yasuyuki Suzuki

Naoto Ishii

Yoshinori Takahashi

Keigo Tanaka

Hironori Ikuta

Osamu Asano

Ichiro Yoshida

Kazuhiro Yokoyama

Masashi Ito

Hiroyuki Sugumi

Kohei Sawada

Toshimi Okada

Kazutomi Kusano

Hiroshi Katoh

Takashi Yoshinaga

Daisuke Shinmyo

Hironobu Hiyoshi

Kiyoaki Kobayashi

Itaru Arimoto

Manabu Shirato

Mutsuko Tabata

Nobuyuki Kurusu

Hiroyuki Suzuki

Tatsuhiro Onogi

Takako Yoshiba

Mamoru Yanagimachi

Hisashi Wakita

Masuyuki Ikeguchi

Miyuki Ohkubo

Kenji Matsui

Kenichi Maeyama

Mai Saeki, Legal Representative

Tomoko Saeki, Legal Representative

Ken-Ichi Nomoto

Takao (deceased) Saeki

A compound represented by the following formula (I), salt thereof, or hydrate thereof, can effectively relieve itch caused by atopic disease or the like: wherein R represents hydroxyl, Calkoxy optionally substituted with Calkoxy, or amino optionally substituted with Calkyl.

4-(3-benzoylaminophenyl)-6,7-dimethoxy-2-methylaminoquinazoline derivatives

An upper surface of a skirting base sectionof a sand coreis provided with a projectionof a column shape. When a slide moldis slidingly moved in a mold clamping direction, a sliding contact sectionof a holding recessed sectionof the slide moldis brought into sliding contact with the projectionto hold the projectionwhile scraping away part of the sand of the projection. The upper surface of the skirting base sectionadjacent to the projectionis also provided with a recessfor recovering the scraped sand, wherein the width of the recessis larger than the diameter of the projectionin the longitudinal direction. The projectioncan be formed in a prismatic or semispherical shape.

Method of installing sand core for casting in mold and sand core for casting

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)], salts thereof or hydrates of the foregoing.

Nitrogen-containing aromatic derivatives

A compound represented by the general formula: wherein Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Y represents an oxygen atom or the like; Rrepresents a Calkoxy group, an optionally substituted Caryloxy group, a group represented by the formula &#x2014;NRRor the like; Rrepresents a hydrogen atom, an optionally substituted Calkyl group, or the like; R, R, R, R, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, an optionally substituted Calkyl group, or the like; Rrepresents a group represented by the formula &#x2014;NRRor the like; and R, R, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, or the like,a salt thereof, or a hydrate of the foregoing.

Compounds represented by the following general formula: [wherein Ais an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xis &#x2014;O&#x2014;, &#x2014;S&#x2014;, etc.; Yis an optionally substituted Caryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tis a group represented by the following general formula: (wherein Eis a single bond or &#x2014;N(R)&#x2014;, Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, etc. and Zrepresents a Calkyl group, a Calicyclic hydrocarbon group, a Caryl group, etc.)],

A compound represented by the general formula: wherein Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Xrepresents a nitrogen atom or a group represented by the formula &#x2014;CR&#x2550;; Y represents an oxygen atom or the like; Rrepresents a Calkoxy group, an optionally substituted Caryloxy group, a group represented by the formula &#x2014;NRRor the like; Rrepresents a hydrogen atom, an optionally substituted Calkyl group, or the like; R, R, R, R, R, R, Rand Reach independently represent a hydrogen atom, a halogen atom, an optionally substituted Calkyl group, or the like; Rrepresents a group represented by the formula &#x2014;NRRor the like; and Rand Reach independently represent a hydrogen atom, an optionally substituted Calkyl group, or the like, a salt thereof, or a hydrate of the foregoing.

The present invention provides a novel nitrogen-containing heterocyclic compound useful as a phosphodiesterase-4 inhibitor, and a medicament comprising the same. Further, the present invention provides a nitrogen-containing heterocyclic compound represented by the following formula, its salt or hydrates thereof, and a medicament comprising the same.

Nitrogen-containing heterocyclic compounds and medicaments containing the compounds

Piperidine compound and pharmaceutical composition thereof

Phthalazine compounds and therapeutic agents for erectile dysfunction

Quinuclidine compounds and drugs containing the same as the active ingredient

In a semiconductor device having a metal wiring conductor connected to a contact hole formed through an interlayer insulator layer formed on a lower level circuit, a lower level tungsten film is deposited under a condition giving an excellent step coverage so as to fill the contact hole, and an upper level tungsten film is further deposited under a condition of forming a film having a stress smaller than that of the lower level tungsten film. The metal wiring conductor is formed of a double layer which is composed of the lower level tungsten film and the upper level tungsten film, and therefore, has a reduced stress in the whole of the film. Thus, there is obtained the tungsten film wiring conductor which fills the inside of the contact hole with no void and therefore has a high reliability, and which has a low film stress. In addition, the number of steps in the manufacturing process can be reduced.

Semiconductor device and method for manufacturing the same

Phthalazine derivatives and remedies for erectile dysfunction

Nitrogenous heterocyclic derivatives and medicine thereof

Fused pyridazine compounds

Growing community of inventors

Ibaraki, Japan

Kazuki Miyazaki