Nitto-denko Corporation

Hokkaido University

Kazuki Hashiba

Takuya Shishido

Hideyoshi Harashima

Yoshiki Maeda

Yusuke Sato

Masamitsu Taguchi

Sachiko Sakamoto

Ayaka Otsu

The present invention addresses the problem of providing lipid nanoparticles which function as gene transfer carriers capable of selective transfer to the liver or spleen. Lipid nanoparticles which contain a pH-sensitive cationic lipid represented by formula (I) [a represents an integer of 3-5; b represents 0 or 1; Rand Reach independently represent a group represented by general formula (A) (Rand Reach independently represent a linear or branched Calkyl group; c represents 0 or 1; v represents an integer of 4-12); and X represents a group represented by general formula (B)(d represents an integer of 0-3; and Rand Reach independently represent a Calkyl group or Calkenyl group, while Rand Rmay form a 5- to 7-membered non-aromatic heterocycle) or represents a 5- to 7-membered non-aromatic heterocyclic group]. (I) (R)(R)C(OH)—(CH)a-(O—CO)b-X. (A): (R)(R)—CH—(CO—O)c-(CH)v-. (B):—(CH)d-N(R)(R).(R)(R)C(OH)—(CH)—(O—CO)-X  (I)(R)(R)—CH—(CO—O)—(CH)-  (A)—(CH)-N(R)(R)  (B)

Lipid nanoparticle

Growing community of inventors

Osaka, Japan

Kazuki Hashiba