International Business Machines Corporation

Agency for Science, Technology and Research

Leland Stanford Junior University

Globalfoundries Inc.

King Abdulaziz City for Science and Technology

Kazuki Fukushima

James L Hedrick

Daniel Joseph Coady

Yi Yan Yang

Urs T Duerig

Armin W Knoll

Alshakim Nelson

Amanda Catherine Engler

Jane Elizabeth Frommer

Julia Elizabeth Rice

Hans Werner Horn

Daniel Sanders

Robert M Waymouth

Sung-Ho Kim

Phillip Joe Brock

Fares D Alsewailem

Jed Walter Pitera

Hareem Tariq Maune

James Lupton Hedrick

Yi-Yan Yang

Jeremy P K Tan

Shaoqiong Liu

Hamid A Almegren

Jeremy Pang Kern Tan

Abdullah M Alabdulrahman

A biodegradable cationic polymer is disclosed, comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a subunit derived from a monomeric diol initiator for the ring-opening polymerization; and an optional endcap group. The biodegradable cationic polymers have low cytotoxicity and form complexes with biologically active materials useful in gene therapeutics and drug delivery.

Biodegradable polymers, complexes thereof for gene therapeutics and drug delivery, and methods related thereto

A cationic star polymer is disclosed of the general formula (1): wherein w' is a positive number greater than or equal to 3, I&#x2032; is a dendritic polyester core covalently linked to w&#x2032; independent peripheral linear cationic polymer chains P&#x2032;. Each of the chains P&#x2032; comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

Cationic polymers for antimicrobial applications and delivery of bioactive materials

Biodegradable cationic block copolymers are disclosed, comprising a hydrophilic block comprising first repeat units derived from a first cyclic carbonyl monomer by ring-opening polymerization, wherein more than 0% of the first repeat units comprise a side chain moiety comprising a quaternary amine group; a hydrophobic block comprising second repeat units derived from a second cyclic carbonyl monomer by ring-opening polymerization; an optional endcap group; and a chain fragment derived from an initiator for the ring opening polymerization. The cationic block copolymers form aqueous micelle mixtures suitable for antimicrobial applications.

Antimicrobial polymers and methods of manufacture thereof

The invention concerns a method for patterning a surface of a material. A substrate having a polymer film thereon is provided. The polymer is a selectively reactive polymer (e.g., thermodynamically unstable): it is able to unzip upon suitable stimulation. A probe is used to create patterns on the film. During the patterning, the film is locally stimulated for unzipping polymer chains. Hence, a basic idea is to provide a stimulus to the polymeric material, which in turn spontaneously decomposes e.g., into volatile constituents. For example, the film is thermally stimulated in order to break a single bond in a polymer chain, which is sufficient to trigger the decomposition of the entire polymer chain.

Patterning nano-scale patterns on a film comprising unzipping copolymers

A cationic bis-urea compound is disclosed of formula (1): wherein:

Cationic bis-urea compounds as effective antimicrobial agents

A salt catalyst comprises an ionic complex of i) a nitrogen base comprising one or more guanidine and/or amidine functional groups, and ii) an oxoacid comprising one or more active acid groups, the active acid groups independently comprising a carbonyl group (C&#x2550;O), sulfoxide group (S&#x2550;O), and/or a phosphonyl group (P&#x2550;O) bonded to one or more active hydroxy groups; wherein a ratio of moles of the active hydroxy groups to moles of the guanidine and/or amidine functional groups is greater than 0 and less than 2.0. The salt catalysts are capable of catalyzing ring opening polymerization of cyclic carbonyl compounds.

Methods of ring opening polymerization and catalysts therefor

A cationic star polymer is disclosed of the general formula (1):I'P&#x2032;]&#x2003;&#x2003;(1),wherein w&#x2032; is a positive number greater than or equal to 3, I&#x2032; is a dendritic polyester core covalently linked to w&#x2032; independent peripheral linear cationic polymer chains P&#x2032;. Each of the chains P&#x2032; comprises a cationic repeat unit comprising i) a backbone functional group selected from the group consisting of aliphatic carbonates, aliphatic esters, aliphatic carbamates, aliphatic ureas, aliphatic thiocarbamates, aliphatic dithiocarbonates, and combinations thereof, and ii) a side chain comprising a quaternary amine group. The quaternary amine group comprises a divalent methylene group directly covalently linked to i) a positive charged nitrogen and ii) an aromatic ring.

A composition of matter comprises a cationic polymer comprising a polycarbonate chain fragment, the polycarbonate chain fragment comprising a repeat unit comprising a side chain moiety containing a quaternary amine group; and a non-charged polymer comprising a polyester chain segment and a poly(alkylene oxide) chain segment; wherein i) the cationic polymer and the non-charged polymer are amphiphilic and biocompatible, ii) the cationic polymer and the non-charged polymer form a mixed complex by non-covalent interactions in water, and iii) the mixed complex is a more effective antimicrobial agent against at least a Gram-negative microbe compared to the cationic polymer and the non-charged polymer alone when tested using otherwise identical conditions.

Antimicrobial compositions, methods of preparation thereof, and uses thereof

A composition comprises a surface modified nanoparticle comprising a core comprising a material selected from the group consisting of organic materials, organometallic materials, inorganic materials, metals, metal oxides, and combinations thereof; and a surface branch covalently linked to the core having the general formula (3): 

Surface modified nanoparticles, methods of their preparation, and uses thereof for gene and drug delivery

A method comprises forming a reaction mixture comprising a terephthalate polyester, a glycol comprising 2 to 5 carbons, and an amidine organocatalyst; and heating the reaction mixture at a temperature of about 120&#xb0; C. or more to depolymerize the terephthalate polyester, thereby forming a terephthalate reaction product comprising a monomeric dihydroxy terephthalate diester; wherein the terephthalate reaction product contains terephthalate oligomers in an amount less than the amount of terephthalate oligomers that would result from i) substituting the amidine organocatalyst with an equimolar amount of a guanidine catalyst and ii) depolymerizing the terephthalate polyester under otherwise identical reaction conditions.

Methods of depolymerizing terephthalate polyesters

Block copolymers include hydrophobic and hydrophilic blocks having repeating units derived from ring opening polymerization of one or more cyclic carbonate monomers. The carbonate monomers are independently selected from compounds of formula (II): wherein each Q' and Qgroup independently represents a hydrogen, an alkyl group, a halide, a carboxy group, an ester group, an amide group, an aryl group, an alkoxy group, or a foregoing Q&#x2032; or Qgroup substituted with a carboxy group or an ester group, at least one Q&#x2032; and Qgroup includes an ester group; each Y independently represents O, S, NH, or NQ&#x2033;; n is an integer from 0 to 6, wherein when n is 0, carbons labeled 4 and 6 are linked together by a single bond; each Q&#x2033; group independently represents an alkyl group, an aryl group, or a foregoing Q&#x2033; group substituted with a carboxy group, or an ester group.

Growing community of inventors

San Jose, CA, United States of America

Kazuki Fukushima