Seiren Kabushiki Kaisha

Seiren Company, Ltd

Kazuhisa Tsujimoto

Hideyuki Yamada

Hiroshi Takagi

Shigeru Nakamori

Masakazu Takahashi

Yoichi Kato

Akimitsu Bamba

Kouichi Kugimiya

Norihisa Kato

Taizo Hamada

Kazunobu Tokunaga

Sadayuki Yuda

Koichi Okano

The purpose of the present invention is to provide a method for using a metal ion solution of low concentration to efficiently form a metal film pattern of excellent accuracy and reliable adhesion on a resin substrate. A resin substrate having a metal film pattern formed thereon is produced by a method that includes the following steps (a) to (e): (a) a step for pattern-printing of a latent image agent () onto the surface of a resin substrate () ; (b) a step for bringing the area imprinted with the latent image agent () into contact with a solution containing metal ions, and forming a metal salt (); (c) a step for bringing the metal salt () into contact with an acidic treatment liquid containing a reducing agent, and reducing the metal salt; (d) a step for forming an electroless nickel plating film () on the area imprinted with the latent image agent; and (e) a step for precipitating an electroless copper plating () onto the surface of the nickel plating film ().

Method for producing a resin substrate having a metal film pattern formed thereon

The present invention relates to an adiponectin production enhancer comprising sericin as an active ingredient, and to a pharmaceutical composition and food and drink comprising sericin. These are effective in the prevention and/or amelioration of various diseases caused by reduction of blood adiponectin level such as arteriosclerosis, fatty liver and diabetes associated with obesity. The enhancer, the pharmaceutical composition and the food and drink according to the invention have excellent adiponectin production enhancing effects as well as high safety and are expected to be broadly applied to a variety of pharmaceutical preparations and food and drink.

Adiponectin production enhancer

The purpose is to prevent, ameliorate or relieve various conditions induced in the dried oral cavity or to improve the stability of a denture during use. A solution for treating a denture or a denture stabilizer comprising sericin can be used.

Use of sericin for improving the feeling in use of denture

The present invention provides a porous body high in safety against environment and living bodies and having a strength high enough to withstand practical use, said porous body comprising, as a skeleton constituent thereof, sericin with an average molecular weight of 30000 to 400000, and having a recovery rate of 10 to 100% after 50% compression.

Porous body formed of sericin

A peptide according to the present invention is selected from the group consisting of: (a) a peptide having the amino acid sequence represented by SEQ ID NO: 1; (b) a peptide having a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having cell death-preventing activity and/or cell growth-promoting activity; and (c) a peptide which has an amino acid sequence having at least 80% homology with the peptide consisting of the amino acid sequence described in (a) above and has cell death-preventing activity and/or cell growth-promoting activity. The peptide has cell death-preventing activity and/or cell growth-promoting activity, is highly safe, and can be produced without difficulty. The peptide is useful as a culture supplement or as an effective component for a cell culture medium.

Physiologically active peptides

An objective of the present invention is to provide a new protein derived from the silkworm middle silk gland and a DNA encoding said protein. The present invention relates to a protein of the following (a) or (b): (a) a protein comprising the amino acid sequence represented by SEQ ID NO: 1; (b) a protein comprising a modified amino acid sequence of the amino acid sequence described in (a) above, in which one or more amino acid residues are deleted, substituted, inserted or added, and having protease activity.

Protein and DNA encoding the same

An objective of the present invention is to provide a means to prevent freeze-induced decrease in protein activity. The present invention relates to a method for preventing freeze-induced decrease in protein activity comprising adding a polypeptide comprising the following amino acid sequence (I) to a protein to be frozen. Further, the present invention relates to use of a polypeptide comprising the following amino acid sequence (I) to produce an agent for preventing freeze-induced decrease in protein activity: 

Method of preventing decrease in the activity of protein due to freezing and use of polypeptide in the production of protein activity decrease preventing agent

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Fukui, Japan

Kazuhisa Tsujimoto