Ezaki Glico Co., Ltd.

Nanoegg Research Laboratories, Inc.

Kazuhisa Sugimoto

Haruyo Sambe

Takashi Kuriki

Yoko Yamaguchi

Hiroshi Kamasaka

Takahisa Nishimura

Yoshiki Kubota

Keiichi Hirata

Hiromi Nishiura

Tomoko Tanaka

Provided is method of maintaining or improving a skin barrier function in a subject comprising orally administering to the subject a composition comprising an oil-soluble extract from red paprika, wherein the oil-soluble extract contains a hexane-soluble component.

Skin dullness suppressing agent, and skin barrier function maintaining or improving agent

An object of the present invention is to provide an anti-skin aging agent that can prevent skin aging such as spots, dullness, wrinkles, sags, and skin roughness. It has been found that resveratrol 3-O-&#x3b1;-glucoside has remarkable anti-skin aging effects such as melanogenesis suppression, hyaluronidase inhibition, anti-oxidization, cell activation, sirtuin gene activation, matrix metalloproteinase suppression, and anti-inflammation, and thus, can be used as an anti-skin aging agent.

Skin aging inhibitor and concentrate of resveratrol 3-O-&#x3b1;-glucoside

Provision of a stable &#x3b1;-lipoic acid. A method for producing &#x3b1;-lipoic acid nanoparticles, the method comprising the steps of: preparing an aqueous dispersion liquid containing &#x3b1;-lipoic acid and a nonionic surfactant; adding a divalent metal salt into the aqueous dispersion liquid, wherein the divalent metal salt is a divalent metal halide, a divalent metal acetate or a divalent metal gluconate; and adding an alkali metal carbonate or an alkali metal phosphate into the aqueous dispersion liquid which has been added with the divalent metal salt, thereby forming &#x3b1;-lipoic acid nanoparticles.

&#x3b1;-Lipoic acid nanoparticles and methods for preparing thereof

A method for extracting a hydrophobic group-containing water-soluble organic compound, comprising the step of bringing an aqueous solution containing the hydrophobic group-containing water-soluble organic compound and a saccharide into contact with a polar organic solvent to obtain an aqueous phase and an organic phase, whereby the hydrophobic group-containing water-soluble organic compound is transferred to the organic phase. The saccharide concentration of the aqueous solution may be at least 12 g per 100 ml of the aqueous solution. The aqueous solution may further contain a phase separation assisting agent. The phase separation assisting agent may be selected from the group consisting of sodium chloride, sodium citrate, magnesium sulfate, and ammonium sulfate.

Method of extracting and method of purifying an effective substance

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Osaka, Japan

Kazuhisa Sugimoto