Kao Corporation

Kazuhisa Sawada

Kotomi Ishimaru

Akira Shimotoyodome

Katsuya Ozaki

Keiji Endo

Masatoshi Tohata

Tohru Kobayashi

Hiroshi Hagihara

Naotake Ogasawara

Tadahiro Ozawa

Noriko Osaki

Yoshihiro Hakamada

Yasunao Wada

Hiroshi Kodama

Junichi Sekiguchi

Shitsu Shikata

Kazuo Kobayashi

An agent for suppressing elevation of blood GIP level, an agent for suppressing elevation of blood insulin level, an agent for lowering blood triglyceride level after meal ingestion and an agent for suppressing elevation of blood glucose level, these agents containing potassium polyglutamates as active ingredients.

Agent for suppressing elevation of blood GIP level, agent for suppressing elevation of blood insulin level, agent for lowering blood triglyceride level after meal ingestion, and agent for suppressing elevation of blood glucose level

An agent for suppressing postprandial elevation of blood insulin concentration, comprising a polyglutamic acid as an active ingredient.

Agent for suppressing postprandial elevation of blood insulin concentration

An agent for suppressing elevation of blood GIP concentration and an agent for preventing or improving obesity, each of which contains a polyglutamic acid as an active ingredient.

Agent for suppressing elevation of blood GIP concentration

An agent for suppressing elevation of a blood triglyceride concentration, comprising a polyglutamic acid as an active ingredient.

Agent for suppressing elevation of blood triglyceride concentration

A microorganism wherein one or more genes selected from the group of genes participating in sporulation in the middle to late stages of sporulation have been deleted or inactivated; and a process for producing a target product (a protein) by use the microorganism. No spore is formed when this microorganism is employed, thereby enabling production of a target product (a protein) while decreasing energy loss, production of a by-product and specific production speed to decrease unnecessary consumption of a medium. Moreover, the production period can be prolonged, whereby the target product (the protein) can be produced efficiently.

Host microorganisms

The present invention provides a recombinant microorganism obtained by transferring, into a host microorganism which is capable of producing protein or polypeptide with increased productivity and which was identified by the present inventors, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by use of the recombinant microorganism.

Recombinant microorganism

The present invention relates to alkaline cellulase variants having an amino acid sequence which exhibits at least 95% homology with the amino acid sequence of SEQ ID NO: 2, wherein said alkaline cellulase variant is mutated to include at least one substitution at (a) position 10, (b) position 16, (c) position 22, (d) position 33, (e) position 39, (f) position 76, (g) position 109, (h) position 242, (i) position 263, (j) position 308, (k) position 462, (l) position 466, (m) position 468, (n) position 552, (o) position 564, or (p) position 608 in SEQ ID NO: 2, or at a position corresponding thereto, wherein said alkaline cellulase variant has alkaline cellulase activity. The present invention also relates to a gene encoding the variant; a vector containing the gene; a transformant containing the vector; and a detergent composition containing the alkaline cellulase variant.

Growing community of inventors

Haga-gun, Japan

Kazuhisa Sawada