Kyowa Hakko Kogyo Co., Ltd.

Kyowa Hakko Kogyo Kabushiki Kaisha

Kazuhisa Fujimoto

Makoto Morimoto

Fusao Tomita

Isao Kawamoto

Hiroshi Sano

Hirofumi Nakano

Kunikatsu Shirahata

Tadashi Ashizawa

Tatsuya Tamaoki

Toru Yasuzawa

Takao Iida

Keiichi Takahashi

Isami Takahashi

Shinzo Ishii

Kozo Asano

Shigeo Katsumata

Michio Ichimura

Yukou Arai

Kozo Asasno

The present invention relates to DC-88A and DC-89A1 and their production. These compounds are obtained by fermentation of microorganisms belonging to the genus Streptomyces. These compounds have antibacterial and anti-tumor activities and are useful as medicaments.

Pyrindamycins A and B and duocarmycin A antibiotics derived from certain

A pharmacologically acceptable acid addition salt of DC-52 with 0.5-2.0 equivalent weight of inorganic acid, sulfonic acid, acidic amino acid, citric acid, transaconitic acid, .alpha.-ketoglutaric acid, itaconic acid, malonic acid or ascorbic acid on the basis of DC-52, having the same degree of antitumor activity as DC-52, is superior to DC-52 in stability at powdering or at preservation.

Salt of DC-52 and a pharmaceutical composition containing the same

Phenazine compounds represented by the formula: ##STR1## wherein R is a hydrogen atom, an unsubstituted or substituted lower alkanoyl group, or an unsubstituted or substituted arylcarbonyl group have antibacterial and anti-tumor activities. Some of these compounds are produced by incubation of a microorganism.

Phenazine carboxylic acid derivatives and a process for production

New substances designated as DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 and represented by the following general formula: ##STR1## wherein (i) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR2## and R.sub.3 represents ##STR3## (designated DC-45-A); (ii) R.sub.1 represents --OH, R.sub.2 represents --CH.sub.2 OH and R.sub.3 represents ##STR4## (designated DC-45-B.sub.1); or (iii) R.sub.1 and R.sub.2 together with the carbon atom therebetween represent the group ##STR5## and R.sub.3 represents ##STR6## (designated DC-45-B.sub.2). DC-45-A, DC-45-B.sub.1 and DC-45-B.sub.2 possess antibiotic and anti-tumor activity and may be obtained by culturing a microorganism of the genus Streptomyces. Preferred strain is Streptomyces bottropensis (FERM-P No. 5219; NRRL 12051).

Antibiotic substances DC-45, and their use as medicaments

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Shizuoka, Japan

Kazuhisa Fujimoto