Astellas Pharma Gmbh

Alps Electric Co., Ltd.

Nippon Steel Corporation

Other

Honda Motor Co., Ltd.

Akiyama Printing Machinery Manufacturing Corp.

Kazuhiro Yokoyama

Hiroaki Tanaka

Jun Maeda

Takanori Koike

Kenji Negoro

Kazutoshi Watanabe

Hajime Takamatsu

Taisuke Takahashi

Tsuyoshi Narusawa

Hiroaki Yamanaka

Yasuhiro Yone

Koji Kato

Makoto Inoue

Hiroshi Nagata

Koichi Yonezawa

Yuki Sawada

Hiroyuki Moritomo

Noriyuki Kawano

Kazuki Miyazaki

Tomoyuki Saito

Susumu Yamaki

Kenichi Onda

Naoyuki Masuda

Yusuke Inagaki

Tadashi Terasaka

Takafumi Shimizu

Issei Tsukamoto

Shinji Hirano

Naoki Ishibashi

Shunichiro Matsumoto

Keita Nakanishi

Takatoshi Kanayama

Yasuharu Urano

Kenichiro Imamura

Yasutaka Kojima

Toru Kontani

Shigeo Matsui

Seiichi Suga

Hideki Suzuki

Shozo Murakami

Satoru Takemori

Katsuyuki Katayama

Katsuyuki Suzuki

Hiroshi Inami

Takashi Ogiyama

Shuichirou Kakimoto

Teiichi Ando

Jun-ichi Shishikura

Hidetsugu Okada

Kenichi Maeyama

Masuyuki Ikeguchi

Takahiro Miyazaki

Chiharu Mori

Masami Akiyama

Syozo Murakami

Fumie Sato

Tokuzi Yamaguchi

Shigetada Furukawa

Tokuji Yamaguchi

Kazuhiro Momose

[Problem] To provide a compound which is useful as an active ingredient for a pharmaceutical composition for preventing or treating urine storage dysfunction, voiding dysfunction, lower urinary tract dysfunction, and the like. [Means for Solution] The present inventors have found that a thiazole derivative substituted with pyrazinylcarbonylamino at the 2-position is an excellent muscarinic Mreceptor-positive allosteric modulator and is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic Mreceptor, thereby completing the present invention. 2-Acylaminothiazole derivative or a salt thereof of the present invention is expected as an agent for preventing or treating bladder/urinary tract diseases associated with bladder contractions via a muscarinic Mreceptor, for example voiding dysfunction such as underactive bladder.

2-acylaminothiazole derivative or salt thereof

[Problem] To provide a compound useful as a MTand/or MTreceptor agonist. [Solution] The present inventors have studied on MTand/or MTreceptor agonists, and have confirmed that indole compounds have the activity. As a result, the present invention is accomplished. That is, a compound represented by formula (I) or a salt thereof according to the present invention has a MTand/or MTreceptor agonistic activity and has a low ability of migrating into central nervous system. Therefore, the compound or a salt thereof can be used as a peripheral MTand/or MTreceptor agonist, and therefore can be used as a therapeutic and/or prophylactic agent for urinary incontinence, particularly stress urinary incontinence and mixed urinary incontinence. 

Indole compound

Thiazole derivatives having pyrazine-2-carbonylamino substituted at the 2-position of the following formula (I): are excellent muscarinic Mreceptor positive allosteric modulators, and are useful for treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic Mreceptor. The 2-acylaminothiazole derivatives and salts thereof can be used for treating bladder or urinary tract diseases, related to bladder contraction by a muscarinic Mreceptor, for example, voiding dysfunctions such as underactive bladder.

As a result of extensive studies on NAD(P)H oxidase inhibitors, the present inventors found that a quinolone derivative having, at the 2-position, an alkyl group substituted with a heteroatom or the like has an excellent NAD(P)H oxidase inhibitory activity, and accomplished the present invention. The compound of the present invention has a reactive oxygen species production inhibitory activity based on the NAD(P)H oxidase inhibitory activity, and therefore can be used as an agent for preventing and/or treating diabetes, impaired glucose tolerance, hyperlipidemia, fatty liver, diabetic complications and the like.

Quinolone derivative

Provided is a compound useful as an N-type Cachannel blocker. As a result of intensive studies of compounds having an action of blocking N-type Cachannels, the present inventors found that a tetrahydroisoquinoline compound of the present invention having a substituent at the 1-position has an action of blocking the N-type Cachannels, an antinociceptive pain action, an antineuropathic pain action, an abdominal pain-inhibitory action and an opioid-induced constipation-improving action, and the present invention has been completed based on these findings. The compound of the present invention can be used as a pharmaceutical composition for preventing and/or treating various pains such as neuropathic pain and nociceptive pain, headaches such as migraine and cluster headache, central nervous system diseases such as anxiety, depression, epilepsy, cerebral stroke and restless legs syndrome, abdominal symptoms such as abdominal pain and abdominal distension, stool abnormalities such as diarrhea and constipation, digestive system diseases such as irritable bowel syndrome, urinary system diseases such as overactive bladder and interstitial cystitis, etc.

1-substituted tetrahydroisoquinoline compound

An upper surface of a skirting base sectionof a sand coreis provided with a projectionof a column shape. When a slide moldis slidingly moved in a mold clamping direction, a sliding contact sectionof a holding recessed sectionof the slide moldis brought into sliding contact with the projectionto hold the projectionwhile scraping away part of the sand of the projection. The upper surface of the skirting base sectionadjacent to the projectionis also provided with a recessfor recovering the scraped sand, wherein the width of the recessis larger than the diameter of the projectionin the longitudinal direction. The projectioncan be formed in a prismatic or semispherical shape.

Method of installing sand core for casting in mold and sand core for casting

To provide a compound which has an excellent activity to modulate the functions of CCR4 or TARC and/or MDC and can be used for the prevention and/or treatment of various inflammatory diseases, allergic diseases, autoimmune diseases and the like. An acylaminopiperidine compound represented by the formula (I) or a pharmaceutically acceptable salt thereof. [Symbols in the formula represent the following meanings; A: a single bond or C-Calkylene, R: phenyl which may be substituted, etc., R: &#x2014;H or C-Calkyl, R: &#x2014;H, C-Calkyl or C-Ccycloalkyl, R: pyrrolidin-2-yl which may be substituted, etc., and D: benzene ring or pyrazole ring].

Acylaminopiperidine compound

A key top of a key switch is formed so as to extend in a horizontal direction, not in a vertical direction. On a rear surface of the key top, a reinforcing member that horizontally extends is mounted on one end portion in the vertical direction and a torsion bar that horizontally extends is rotatably supported on the other end portion in the vertical direction. When the key top is pressed against a biasing force of an elastic member, the reinforcing member prevents the key top from deforming.

Key switch and keyboard input device using the same

The keyboard apparatus includes a plurality of key switches manipulated by keytops and a backlight means comprising an EL sheet for illuminating the operation side S constituted of the keytops from under it wherein the key switches are provided with permeable keytops and impermeable character portions and the backlight means has light emission positions allocated corresponding to key placements.

Keyboard apparatus the operation side of which can be illuminated

A keyboard apparatus is able to be made thinner without sacrificing ease of operation or feel. The keyboard apparatus is less expensive and permits easier assembly. Through holes are formed in a metal plate at the locations where retaining members are to be installed, then the resinous retaining members are inserted in the through holes to be mounted on the metal plate. For this purpose, the retaining members are formed by a molding method referred to as an outsert molding method. Supporting members are shaped so that they may be snapped in the retaining members. The retaining members are combined with a membrane switch, the supporting members, a key top, and an elastic member.

Thin keyboard apparatus

A keyboard is constructed so that a ratio of a dimension between a first latching portion of a first lever and a pivotally supporting portion thereof to a dimension between this pivotally supporting portion thereof and a second latching portion thereof is equal to a ratio of a dimension between a first latching portion of a second lever and another pivotally supporting portion thereof to a dimension between this pivotally supporting portion thereof and a second latching portion thereof. Thus, when the key top descends, the second latching portions of the first and second levers are placed outside the first latching portions of the first and second levers. Consequently, reduction in thickness of a keyboard is achieved.

Thin keyboard

A dampening water feed roller, characterized by a process of manufacturing which comprises forming a flame sprayed layer of a ceramic material composed of Al.sub.2 O.sub.3, TiO.sub.2, or a mixture of Al.sub.2 O.sub.3 and TiO.sub.2 on the peripheral surface of a metallic roller, subjecting the flame sprayed ceramic layer to a pore-occluding treatment with a hydrophilic SiO.sub.2 type inorganic pore-occluding agent, and grinding the treated layer to surface roughness of not more than 1.6 S. The roller permits supply of the dampening water without using the additives such as isopropyl alcohol in the dampening water.

Dampening water feed roller for planographic printing press

A keyboard key top mounting structure including a plurality of lever support means provided on the back of a key top, the lever support means being each provided with wing portions for abutment therewith of a lever to prevent the lever from pivoting during mounting of the lever, and a plurality of lever sliding members provided on the side of a stationary member and each having a lever sliding slot, in which the lever is supported by the lever support means and inserted into the sliding slots.

Keyboard key top mounting structure

A method for classifying wet coal for obtaining coal charges suitable for use in a coke oven comprising classifying the wet coal directly in a cylindrical screen which rotates and revolves around an eccentric rotation shaft while blowing a high pressure gas stream to the screen to eliminate adhesion of the wet coal particles to the screen. The method enables a continuous and consistent classification of wet coals without the clogging of the screen and the dust pollution. The cokes obtained by dry distillation of the coal classified by the present method show high quality.

Method for classification of coals for coke production

Growing community of inventors

Tokyo, Japan

Kazuhiro Yokoyama