Mitsubishi Gas Chemical Company, Inc.

Mitbushi Gas Chemical Company, Inc.

Kazuhiro Sugamura

Teizi Urakami

Mitsunori Oda

Chieko Itoh

Hisao Kobayashi

Toshio Nagai

Takafumi Abe

Shuji Ebata

Hirofumi Higuchi

Taiji Matsuzaki

There is disclosed a process for efficiently producing hydrogen cyanide at a reaction temperature of preferably 250.degree. to 550.degree. C. by a catalytic dehydrative reaction of formamide which comprises employing as a catalyst, a manganese oxide (MnO) and/or a magnesium oxide (MgO) each modified with an alkali metal (Na, K, Rb, Cs, etc. ). The above process is capable of producing hydrogen cyanide at an enhanced conversion efficiency of formamide and at a high selectivity while minimizing the by-production of ammonia. The use of the catalyst comprising as a principal component, MnO modified with an alkali metal is particularly effective in prolonging its service life and enables a long-term stable operation.

Process for producing hydrogen cyanide

The present invention provides a process for producing oxazopyrroloquinolines which comprises culturing microorganisms to produce pyrroloquinolinequinone and adding .alpha.-amino acids or monomethylamine to the resulting culture broth which contains the pyrroloquinolinequinone and from which cells of microorganisms are not separated, thereby to convert the pyrroloquinolinequinone to the corresponding oxazopyrroloquinolines. The thus obtained oxazopyrroloquinolines include novel compounds. The present invention further provides aldose reductase inhibitors, diabetic combined disease curing agents, immunopotentiating agents and liver disease inhibiting agents which contain as active ingredient these oxazopyrroloquinolines having excellent physiological activity.

Process for producing oxazopyrroloquinolines, novel

Oxazopyrroloquinolines and use of oxazopyrroloquinolines

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Niigata, Japan

Kazuhiro Sugamura