Shionogi Company Limited

Kazuhiro Shirahase

Mitsuaki Ohtani

Takaharu Matsuura

Tadashi Yoshida

Shigeru Matsutani

Yasuhiko Fujii

Hitoshi Arita

Kenji Sugita

Kazushige Tanaka

The present invention relates to the new thielocin derivatives, which exhibit phospholipase A.sub.2 inhibitory activity of the formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.6, R.sup.7, and R.sup.8 are independently hydrogen, lower alkyl, lower alkoxy, hydroxy, or halogen;

Phospholipase A.sub.2 inhibitor

Aromatic-sulfonamide-type hydroxamic acid derivative

Sulfonylamino substituted bicyclyl hydroxamic acid derivatives of the formula: ##STR1## wherein R.sup.1 and R.sup.2 each is hydrogen or lower alkyl; R.sup.3 is hydrogen, lower alkyl, lower alkoxy, hydroxy or halogen; X is alkylene or alkenylene: Y is methylene or oxygen; and n is 0, 1, or 2, or the pharmaceutically acceptable salt thereof. These compounds have an advanced antagonistic activity to thromboxane A.sub.2 (TXA.sub.2)-receptor and are useful for the treatment of thrombosis, vasoconstriction, or bronchoconstriction, and the like disease which are induced by TXA.sub.2.

Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid

Growing community of inventors

Neyagawa, Japan

Kazuhiro Shirahase