Shionogi Company Limited

Kazuhiro Shima

Takayuki Tsukada

Yusuke Suzuki

Yasushi Takagishi

Masayoshi Inoue

Yoshitaka Tomoda

Takashi Hayashi

Noboru Nagafuzi

Hirotane Kagawa

Eizo Hirai

A process for preparing a coated composition comprising a pharmaceutically active substance stable to heat, which comprises centrifugally granualting a mixture comprising said active substance and a first thermomelting material as a binder under heating without using any solvent and coating the resultant granules with a second thermomelting material as a coating material under heating, the melting point of the second thermomelting material being lower than that of the first thermomelting material.

Coated composition and its preparation process

Stable freeze-dried preparations of an anticancer platinum complex, i.e. glycolato-cis-diammineplatinum (II), containing at least one member selected from the group consisting of glucan, water-soluble vinyl polymer, and polyethylene glycol as stabilizers, are very useful in the treatment of various cancers.

Stable freeze-dried preparations of an anticancer platinum complex

A lyophilized preparation of 7.beta.-difluoromethylthioacetamido-7.alpha.-methoxy-3-[1-(2-hydroxyalkyl) -1H-tetrazol-5-yl]-thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid alkali metal salt containing glucose, fructose, maltose, or an alkali metal salt of mineral acid or carboxylic acid as a stabilizer.

Stable antibacterial lyophilizates

A stable preparation of a lyophilized .beta.-lactam antibacterial containing a 7.beta.-(.alpha.-carboxy-.alpha.-arylacetamido)-7.alpha.-methoxy-3-heteroc yclic thiomethyl-1-dethia-1-oxa-3-cephem-4-carboxylic acid (I) alkali metal salt as the antibacterial component and a sugar or sugar alcohol compound as the stabilizing agent. ##STR1## (wherein Ar is a p-hydroxyaryl group and

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Nara, Japan

Kazuhiro Shima