Asahi Kasei Chemicals Corporation

Asahi Kasei Kabushiki Kaisha

Sanwa Cornstarch Co., Ltd.

Kazuhiro Obae

Ichiro Ibuki

Naoya Yoshida

Mitsuo Yamashita

Masaaki Endo

Masayuki Kakizawa

Naoaki Yamasaki

Etsuo Kamada

Shun'ichi Gomi

Hideki Amakawa

Takumi Magome

Yohsuke Honda

Ichirou Ibuki

Naoaki Yamazaki

Yosuke Honda

Yoshihito Yaginuma

Shinji Matsui

Hiroyuki Ito

Michihiro Sunako

Junichi Takahara

Yasuhiko Ono

Shozo Kaneyama

Eishi Wakamiya

Hanayo Kodama

Michihiro Sunago

Hirokazu Matsui

Kenji Watanabe

Hiroyuki 1-10-15-3 Kitanijyunanajohigashi Ito

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 &#x3bc;m, but less than 250 &#x3bc;m; an apparent specific volume of 2 to less than 15 cm/g; and an organic carbon content from residual impurities, which is defined by the total organic carbon content (%) during 1% NaOH extraction to the total organic carbon content (%) during pure water extraction, of over 0.07 to 0.3%.

Cellulose powder

A composite particle comprising from 50 to 80 parts by mass of cellulose, from 10 to 40 parts by mass of an inorganic compound and from 4 to 11 parts by mass of hydroxypropyl cellulose based on 100 parts by mass of a total of contents of the cellulose, the inorganic compound and the hydroxypropyl cellulose.

Composite particles including cellulose, inorganic compound, and hydroxypropyl cellulose

The present invention relates to a cellulose powder usable for a satisfactory orally disintegrating tablet having excellent compression moldability and well-balanced tablet moldability and disintegration properties, which can obtain excellent ingestion feel without feeling roughness and dryness in the oral cavity, and more particularly to a cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of not less than 10 &#x3bc;m but less than 100 &#x3bc;m, and a primary particle ratio of 50% or more.

Cellulose micropowder

Disclosed is a tablet containing anhydrous calcium hydrogen phosphate, granules (A) which contain sugars, and granules (B) which contain nuclear particles having a diameter of 10-500&#x3bc;m, medicine and a film coating, and which have a particle diameter of 700&#x3bc;m or less. The present invention enables tablet-making difficulties during the manufacture of the tablet to be suppressed. In addition, the tablet has an appropriate hardness, an excellent disintegration time, and feels very good to ingest.

Orally disintegrating tablet containing bitterness-masking granules

This cellulose powder has: an average degree of polymerization of 100 to 350; a weight average particle size of over 30 &#x3bc;m, but less than 250 &#x3bc;m; an apparent specific volume of 2 to less than 15 cm/g; and a particle size distribution sharpness of 1.5 to 2.9.

Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding state. Also provided are composite particles which permit direct compressing in an open feed manner and which suffer from little compressing trouble and exhibit high shapability. When shaped together with an active ingredient, the composite particles provide shaped bodies which have uniform weight, uniform active ingredient content, and high hardness and which suffer from less galling.

Composite particles which contain both cellulose and inorganic compound

A coating film comprising ethyl cellulose as a component A and an (ethyl acrylate)-(methyl methacrylate) copolymer or a plasticized vinyl acetate polymer as a component B, and having a tensile elongation of 150% or more and a tensile strength of 9 N or more.

Coating film, and granules and tablets each utilizing same

Functional starch powder of 400% or more water retention capacity, 5 hr or more collapse time and 200 g or more gel indentation load. This functional starch powder is produced through the step of heating a starch raw material in the presence of water at 60 to 150&#xb0; C. so as to swell starch particles of the starch raw material and the subsequent step of drying the thus swollen starch particles so as to obtain a powder mixture comprising starch particles and, lying in the exterior thereof, amylose and amylopectin.

Functional starch powder

Disclosed is a solid preparation which comprises at least one active ingredient and at least one dissolution-controlling base substance and can be formed by compression molding, wherein the dissolution-controlling base substance contains 5.0 to 99.9% by weight (inclusive) of a modified starch having a moisture retaining capacity of 400% or more and a gel indentation load of 200 g or more, containing a water-soluble ingredient in an amount of 40 to 95% by weight, having particles passing through a 75 &#x3bc;m-mesh sieve in the proportion of 90% by weight or more and particles passing through a 32 &#x3bc;m-mesh sieve in the proportion of 20% by weight or more, and having an average particle diameter of not smaller than 20 &#x3bc;m and smaller than 50 &#x3bc;m.

Controlled release solid preparation

Provided are composite particles which exhibit excellent fluidity and high liquid retentivity and which exhibit high fluidity even in a liquid-holding sate. Also provided are composite particles which permit direct compressing in an open feed manner and which suffer from little compressing trouble and exhibit high shapability. When shaped together with an active ingredient, the composite particles provide shaped bodies which have uniform weight, uniform active ingredient content, and high hardness and which suffer from less galling.

A porous cellulose aggregate characterized by having a secondary aggregate structure resulting from aggregation of primary cellulose particles, having a pore volume within a particle of 0.265 to 2.625 cm/g, containing I-type crystals and having an average particle size of over 30 to 250 &#x3bc;m, a specific surface area of 0.1 to less than 20 m/g, a repose angle of 25&#xb0; to less than 44&#xb0; and a swelling degree of 5% or more, and characterized by having the property of disintegrating in water.

Porous cellulose aggregate and molding composition thereof

A porous cellulose aggregate which has a secondary aggregation structure formed by the aggregation of primary cellulose particles, has a pore volume within a particle of 0.265 cm/g to 2.625 cm/g, contains I type crystals, has an average particle diameter of more than 30 &#x3bc;m and 250 &#x3bc;m or less, has a specific surface area of 1.3 to 20 cm/g, has an angle of repose of 25&#xb0; or more and less than 44&#xb0;, and has the property that it collapses in water.

Porous cellulose aggregate and formed product composition comprising the same

Disclosed are a processed starch powder in which the amount of water soluble component is greater than 2 wt % but less than 10 wt %, the water retention amount is greater than 600% and 1500% or less, and which comprises nonbirefringent particles, and a manufacturing method thereof.

Growing community of inventors

Tokyo, Japan

Kazuhiro Obae